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Onchocerciasis Elimination Program for the Americas — OEPA – October 2005. Lymphatic Filariasis Elimination in the Americas 5 th Regional Program Review Group (RPRG) Meeting (San José, Costa Rica) . Onchocerciasis Elimination Program for the Americas (OEPA).
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Lymphatic Filariasis Elimination in the Americas
5th Regional Program Review Group (RPRG) Meeting(San José, Costa Rica)
Headquartered in Guatemala, OEPA is the technical and coordinating body of a multi-national, multi-agency coalition that acts under the 1991 Resolution XIV of XXXV Directing Council of the Pan American Health Organization calling for the elimination of all onchocerciasis morbidity from the Americas by the year 2007.
57th WHA, May 19, 2004
IACO 2003, Cartagena, Colombia
Merck & Co.
9. North-eastern Focus
8. North-central Focus
10. Southern Focus (Amazonas/Bolivar)
11. Amazonas-Roraima Focus
1. Oaxaca Focus
2. Northern Chiapas Focus
3. Southern Chiapas Focus
4. Cuilco Focus (Huehuetenango)
5. Central Focus:
6. Escuintla , Guatemala Focus
12. López de Micay Focus
7. Santa Rosa Focus
13. Esmeraldas/ Pichincha Focus
- Cayapas River
- Santiago River
- Onzole River
- Satellite Foci:
(Canandé and others)
*UTG(2): UTG multiplied by two.
6-monthly mass distributions of Mectizan® in all endemic areas, covering at least 85% of the eligible population.
Two primary goals:
4. 2. 1. Entomology
The absence, or near absence, of infective-stage larvae in the vector population as determined by PCR in a minimum sample size of 10,000 flies for each endemic community tested.
The absence of detectable infection (as evidenced by microfilariae, nodules, immunological or other proven tests) in untreated children reaching the age of 5. A 5-year cumulative incidence rate of less than 1 new case per 1000 susceptible children is acceptable.
The absence of detectable infection in untreated, new residents who have migrated into an endemic area where transmission has been interrupted (1 new case per 1000 susceptible individuals).
SIMON: A simulation of numbers of infected persons in the population of Corriente Grande following continual six-monthly distribution of ivermectin. Proportion of non- receivers 2.0%. Each line represents one of 100 model replicates.
Adult Worm Negative
SIMON: A generated probability of eliminating all living female O. volvulus from the human population of Corriente Grande, expressed as the proportion of uninfected persons remaining in the population each year
Source: Davies, 2005, unpublished