activator target

1. 2020/8/1 Enzyme Target & Activator & Inhibitor Screening Service - Profacgen  (https://www.profacgen.com) Home (/) Services Products APP & TECH Contact Us About Us (https://www.profacgen.com/contact- (https://www.profacgen.com/about- us.htm) us.htm) Enzyme Target & Activator & Inhibitor Screening Service Home (http://www.profacgen.com) / Services  Sign In (https://www.profacgen.com/SignIn.aspx) / Register / Protein Analysis (https://www.profacgen.com/protein-analysis.htm) (https://www.profacgen.com/SignUp.aspx) / Enzyme Activity Assay Service (https://www.profacgen.com/enzyme-activity- assay-service.htm) / Enzyme Target & Activator & Inhibitor Screening Service https://www.profacgen.com/Enzyme-targe-screening.htm 1/5

2. 2020/8/1 Enzyme Target & Activator & Inhibitor Screening Service - Profacgen Enzyme Target & Activator & Inhibitor Screening Service Profacgen offers a comprehensive list of high-throughput screening services to specifically and efficiently identify potential enzyme substrates, activators and inhibitors. Enzymes participate in numerous physiological activities including signal transduction, cell surface recognition and protein modification. To determine possible targets of an enzyme, Profacgen has developed a highly efficient screening system to select candidate substrates, inhibitors or activators by detection of fluorescence, chemo-luminescence or isotopic signal. Generally, the candidate molecules can be selected or synthesized and then immobilized on a solid surface. Detection is performed after incubation with the target enzyme according to the specific experimental design. Profacgen provides enzyme target screening service for kinase, phosphatase, protease, methyltransferase, glycosyltransferase, acetyltransferase and so on. You can profile your target enzyme against thousands of substrate compounds or proteins, or study various types of protein modifications including phosphorylation, methylation, ubiquitination, SUMOylation, NEDDylation, and nitrosylation. Profacgen https://www.profacgen.com/Enzyme-targe-screening.htm 2/5

3. 2020/8/1 Enzyme Target & Activator & Inhibitor Screening Service - Profacgen offers thousands of substrates from sources including human, rat, mouse, chicken and cow etc. We also have phosphorylation library containing phosphorylation sites for different recognition sites (threonine, serine or tyrosine) of kinases or phosphatases. Our enzyme target screening service will ensure the discovery and identification of novel enzymatic targets for you. Profacgen also provides activator or inhibitor screening service by adding candidate compounds together with target enzyme into the substrate. The effect of candidate compounds on the kinetics of the given enzymatic reaction can be quantified by the determination of EC50 or IC50 compared to control groups. Illustration of Different Detection Modes Enzyme target & activator & inhibitor screening service can be applied to the following aspects: Identification of novel substrates for known enzymes Identification of substrates for orphan or new enzymes Identification of phosphorylation or proteolytic sites Evaluation of activators or inhibitors of enzymes Elucidation of signal transduction pathways Enzyme profiling in disease states or under different treatments (drug, growth factors, hormones, etc.) Fingerprinting difference in substrate specificity among different enzymes Our advantages: https://www.profacgen.com/Enzyme-targe-screening.htm 3/5

4. 2020/8/1 Enzyme Target & Activator & Inhibitor Screening Service - Profacgen Short turn-around time High efficiency Optimized experimental scheme Consistent results Customized service Combinatorial libraries available to fine-tune substrate sequence We offer customized enzyme substrate arrays to suit your requirements. Please contact us for details of our customized enzyme target & activator & inhibitor screening service. SERVICES  Protein Production (https://www.profacgen.com/protein-production.htm)   Bioinformatics Platform Introduction  (https://www.profacgen.com/Bioinformatics-Platform-Introduction.htm)  Protein Analysis (https://www.profacgen.com/protein-analysis.htm)  Complement Assays (https://www.profacgen.com/services/protein-analysis/c…  * Enzyme Activity Assay Service (https://www.profacgen.com/enzyme-activity-…  * In Vitro Protein Kinase Assay Service (https://www.profacgen.com/services/prote… * Cell-based Kinase Assays (https://www.profacgen.com/cell-based-kinase-assay… * CYP Inhibition Screen Assay Using LC-MS/MS (https://www.profacgen.com/servi… * Enzyme Activity Assay (https://www.profacgen.com/services/protein-analysis/en… * Enzyme Target & Activator & Inhibitor Screening Service (https://www.profacgen.… * Nucleic Acid-Protein Interactions (https://www.profacgen.com/services/protei…  * Optogenetics services (https://www.profacgen.com/services/optogenetics-se… * Plasma Protein Binding Assay (https://www.profacgen.com/services/protein-… * Protein Aggregation Analysis (https://www.profacgen.com/protein-aggregati… * Protein Interaction Analysis Services (https://www.profacgen.com/protein-int…  * Screening and Profiling Services (https://www.profacgen.com/screening-and-…  * Transcription Factor Analysis (https://www.profacgen.com/transcription-fact… * https://www.profacgen.com/Enzyme-targe-screening.htm 4/5

5. 2020/8/1 Enzyme Target & Activator & Inhibitor Screening Service - Profacgen Biomarker Discovery and Development Service (https://www.profacgen.com/… * Genotoxic Impurities Analysis (https://www.profacgen.com/services/protein-… *  Drug Development (https://www.profacgen.com/drug-development.htm)  INQUIRY (https://www.profacgen.com/order.htm?i1=Enzyme Target & Activator & Inhibitor Screening Service) CONTACT US  Email: info@profacgen.com  Tel: 1-631-448-8149  Fax: 1-631-938-8127  45-1 Ramsey Road, Shirley, NY 11967, USA Copyright ©2010 - 2020 Profacgen. All rights reserved. | Terms and Conditions (https://www.profacgen.com/term-and- conditions.htm) | Privacy Policy (https://www.profacgen.com/privacy-policy.htm) https://www.profacgen.com/Enzyme-targe-screening.htm 5/5