bch 400 600 introductory biochemistry l.
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BCH 400/600 – Introductory Biochemistry. Instructor: David Shintani Office: 311C Fleischmann Ag. Lab: 308 Fleischmann Ag. E-mail: shintani@unr.edu Phone: (775) 784-4631. After BCH 400. BCH 400 is heavy on content!!!. Before BCH 400. Come to class!!!!!!. Try not to fall behind!!.

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bch 400 600 introductory biochemistry

BCH 400/600 – Introductory Biochemistry

Instructor: David Shintani

Office: 311C Fleischmann Ag.

Lab: 308 Fleischmann Ag.

E-mail: shintani@unr.edu

Phone: (775) 784-4631

before bch 400

After BCH 400

BCH 400 is heavy on content!!!

Before BCH 400
slide5
Review lecture notes.

http://www.ag.unr.edu/shintani/bch400-600/index.html

  • Read book chapters.
participate in the clicker system

Participate in the clicker system!!!

20 extra credit points!!

slide9

Feel Free

to see me!

My office hours are Tuedays from 2:00 to 3:00 PM

Or e-mail me for a private audience

what is biochemistry
What is Biochemistry?
  • Biochemistry = chemistry of life.
  • Biochemists use physical and chemical principles to explain biology at the molecular level.
  • Basic principles of biochemistry are common to all living organism
how does biochemistry impact you
How does biochemistry impact you?
  • Medicine
  • Agriculture
  • Industrial applications
  • Environmental applications
principle areas of biochemistry
Principle Areas of Biochemistry
  • Structure and function of biological macromolecules
  • Metabolism – anabolic and catabolic processes.
  • Molecular Genetics – How life is replicated. Regulation of protein synthesis
once upon a time a long long time ago
Once upon a time, a long long time ago…..

Vitalism: idea that substances and processes associated with living organisms did not behave according to the known laws of physics and chemistry

Evidence:

  • Only living things have a high degree of complexity
  • Only living things extract, transform and utilize energy from their environment
  • Only living things are capable of self assembly and self replication
slide16

1828 Friedrich Wohler

  • Dead Biochemist #1

Fallacy #1: Biochemicals can only be produced by living organisms

fallacy 2 complex bioconversion of chemical substances require living matter
Fallacy #2: Complex bioconversion of chemical substances require living matter

Dead Biochemists #2

  • 1897 Eduard Buchner

Glucose + Dead Yeast = Alcohol

fallacy 2 complex bioconversion of chemical substances require living matter18
Fallacy #2: Complex bioconversion of chemical substances require living matter
  • Emil Fischer

Dead Biochemists #3

slide19

1926 J.B. Sumner

Fallacy #2: Complex bioconversion of chemical substances require living matter

Dead Biochemists #4

slide20

Findings of other famous dead biochemist

  • 1944 Avery, MacLeod and McCarty identified DNA as information molecules
  • 1953 Watson (still alive) and Crick proposed the structure of DNA
  • 1958 Crick proposed the central dogma of biology
organization of life
Organization of Life
  • elements
  • simple organic compounds (monomers)
  • macromolecules (polymers)
  • supramolecular structures
  • organelles
  • cells
  • tissues
  • organisms
elements of life
Elements of Life

Most abundant, essential for all organisms: C, N, O, P, S, H

Less abundant, essential for all organisms : Na, Mg, K, Ca, Cl

Trace levels, essential for all organism: Mn, Fe, Co, Cu, Zn

Trace levels, essential for some organisms: V, Cr, Mo, B, Al, Ga, Sn, Si, As, Se, I,

many important biomolecules are polymers
Many Important Biomolecules are Polymers

lipids

proteins

carbo

nucleic acids

monomer

polymer

supramolecular

structure

lipids

monomer

polymer

supramolecular

structure

Lipids
proteins

monomer

amino acid

polymer

protein subunit

supramolecular

structure

Enzyme complex

Proteins
carbohydrates
Carbohydrates

monomer

polymer

supramolecular

structure

nucleic acids
Nucleic Acids

monomer

polymer

supramolecular

structure

slide30

Common theme:

Monomers form polymers through condensations

Polymers are broken down through hydrolysis.

cellular organization of an e coli cell
Cellular Organization of an E. coli Cell

200 – 300 mg protein / mL cytoplasm