Quantifying Basepair Isostericity Jesse Stombaugh 1 , Craig L. Zirbel 2 , Eric Westhof 4 , and Neocles B. Leontis 3,*
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Jesse Stombaugh1, Craig L. Zirbel2, Eric Westhof4, and Neocles B. Leontis3,*
1 Department of Biological Sciences, 2 Department of Mathematics and Statistics, 3Department of Chemistry and Center for Biomolecular Sciences, Bowling Green State University, Bowling Green, OH 43403. 4 Architecture et réactivité de l’ARN, Université Louis Pasteur de Strasbourg,Institut de Biologie Moléculaire et Cellulaire du CNRS, 15 rue René Descartes, F-67084 Strasbourg, France.
Online Basepair Catalog: http://rna.bgsu.edu/FR3D/basepairs
To compute the IsoDiscrepancy index (IDI) we calculate:
The difference between C1’-C1’ distances for the two basepairs, denoted by ∆c.
The distance in the plane between the C1’ atoms of the second base when the first bases have the same orientation, denoting this by t1.
The rotation in the plane of the second base relative to the first base (cWW and tWS) or the flipping of the second base to bring it into the same orientation as the first base
Neocles Leontis, P.I.
BGSU – Mathematics And Statistics.
Institut de Biologie Moléculaire et Cellulaire du CNRS
U.C. – Berkeley
MRC Laboratory of Molecular Biology
JS is funded by NBL’s RCE grant, which is supported by Bowling Green State University’s ‘Research Capacity Expansion Program’ with funds provided by the Ohio board of Regents Research Incentive Fund.Acknowledgements