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CDKN1A

https://www.creativebiomart.net/symbolsearch_CDKN1A.htm<br>This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]

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CDKN1A

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  1. 2020/3/28 cdkn1a Protein, cyclin-dependent kinase inhibitor 1A (p21, Cip1) - Creative BioMart (/) Product Search cat#, product name, abbr, or keywords  You Position: Home (/) /  Products (/Products-gd.htm) /  cdkn1a cdkn1a (https://www.addtoany.com/share#url=https%3A%2F%2Fwww.creativebiomart.net%2Fsymbolsearch_CDKN1A.htm&title=cdkn1a%20Protein%2C%20cyclin dependent%20kinase%20inhibitor%201A%20(p21%2C%20Cip1)%20-%20Creative%20BioMart) Official Full Name cyclin-dependent kinase inhibitor 1A (p21, Cip1) Background This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010] Synonyms CDKN1A; cyclin-dependent kinase inhibitor 1A (p21, Cip1); P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1; cyclin-dependent kinase inhibitor 1; DNA synthesis inhibitor; CDK-interacting protein 1; CDK-interaction protein 1; wild-type p53-activated fragment 1; melanoma differentiation associated protein 6; Recombinant Proteins Cell & Tissue Lysates Cat.#: CDKN1A-1053H Tag: GST Source (Host): Wheat Germ Species: Human Product name Recombinant Human CDKN1A Protein, GST-Tagged (/recombinant-human-cdkn1a-protein-gst-tagged-488734.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-1053H)Recombinant+Human+CDKN1A+Protein%2c+GST-Tagged) Cat.#: CDKN1A-169H Tag: N/A Source (Host): E. coli Species: Human Product name Recombinant Human Cyclin-dependent Kinase Inhibitor 1A (p21, Cip1) (/description_4555_8.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-169H)Recombinant+Human+Cyclin-dependent+Kinase+Inhibitor+1A+(p21%2c+Cip1)) Cat.#: CDKN1A-116H Tag: His Source (Host): E. coli Species: Human Product name Recombinant Human CDKN1A Protein, His-tagged (/recombinant-human-cdkn1a-protein-his-tagged-481077.htm) https://www.creativebiomart.net/symbolsearch_CDKN1A.htm 1/5

  2. 2020/3/28 cdkn1a Protein, cyclin-dependent kinase inhibitor 1A (p21, Cip1) - Creative BioMart +Inquiry (/Order.aspx?i1=(CDKN1A-116H)Recombinant+Human+CDKN1A+Protein%2c+His-tagged) Cat.#: CDKN1A-30053TH Tag: N/A Source (Host): E. coli Species: Human Product name Recombinant Human CDKN1A (/description_62144_12.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-30053TH)Recombinant+Human+CDKN1A) Cat.#: CDKN1A-311H Tag: His|MBP Source (Host): E. coli Species: Human Product name Recombinant Human CDKN1A protein, His/MBP-tagged (/recombinant-human-cdkn1a-protein-hismbp-tagged-468463.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-311H)Recombinant+Human+CDKN1A+protein%2c+His%2fMBP-tagged) Cat.#: CDKN1A-312H Tag: His|MBP Source (Host): E. coli Species: Human Product name Recombinant Human CDKN1A protein, His/MBP-tagged (/recombinant-human-cdkn1a-protein-hismbp-tagged-468464.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-312H)Recombinant+Human+CDKN1A+protein%2c+His%2fMBP-tagged) Cat.#: CDKN1A-4837H Tag: GST Source (Host): E. coli Species: Human Product name Recombinant Human Cyclin-Dependent Kinase Inhibitor 1A, GST-tagged (/description_35005_12.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-4837H)Recombinant+Human+Cyclin-Dependent+Kinase+Inhibitor+1A%2c+GST-tagged) Cat.#: CDKN1A-7157H Tag: His Source (Host): E. coli Species: Human Product name Recombinant Human Cyclin-Dependent Kinase Inhibitor 1A (p21, Cip1), His-tagged (/description_108580_12.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-7157H)Recombinant+Human+Cyclin-Dependent+Kinase+Inhibitor+1A+(p21%2c+Cip1)%2c+His-tagged) Cat.#: CDKN1A-7158H Tag: His Source (Host): E. coli Species: Human Product name Recombinant Human CDKN1A, His-tagged (/description_397088_12.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-7158H)Recombinant+Human+CDKN1A%2c+His-tagged) Cat.#: Cdkn1a-1774M Tag: His Source (Host): E. coli Species: Mouse Product name Recombinant Mouse Cdkn1a protein, His-tagged (/recombinant-mouse-cdkn1a-protein-his-tagged-499650.htm) +Inquiry (/Order.aspx?i1=(Cdkn1a-1774M)Recombinant+Mouse+Cdkn1a+protein%2c+His-tagged) Cat.#: CDKN1A-3220M Tag: His Source (Host): Mammalian Cells Species: Mouse https://www.creativebiomart.net/symbolsearch_CDKN1A.htm 2/5

  3. 2020/3/28 cdkn1a Protein, cyclin-dependent kinase inhibitor 1A (p21, Cip1) - Creative BioMart Product name Recombinant Mouse CDKN1A Protein (/recombinant-mouse-cdkn1a-protein-440016.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-3220M)Recombinant+Mouse+CDKN1A+Protein) Cat.#: Cdkn1a-1251R Tag: His|T7 Source (Host): E. coli Species: Rat Product name Recombinant Rat Cdkn1a protein, His & T7-tagged (/recombinant-rat-cdkn1a-protein-his-t7-tagged-490716.htm) +Inquiry (/Order.aspx?i1=(Cdkn1a-1251R)Recombinant+Rat+Cdkn1a+protein%2c+His+%26+T7-tagged) Cat.#: CDKN1A-793R Tag: His Source (Host): Mammalian Cells Species: Rhesus Macaque Product name Recombinant Rhesus monkey CDKN1A Protein, His-tagged (/recombinant-rhesus-monkey-cdkn1a-protein-his-tagged-457442.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-793R)Recombinant+Rhesus+monkey+CDKN1A+Protein%2c+His-tagged) Cat.#: CDKN1A-5966C Tag: His Source (Host): Mammalian Cells Species: Chicken Product name Recombinant Chicken CDKN1A (/description_419133_12.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-5966C)Recombinant+Chicken+CDKN1A) Cat.#: CDKN1A-6910Z Tag: His Source (Host): Mammalian Cells Species: Zebrafish Product name Recombinant Zebrafish CDKN1A (/description_427155_12.htm) +Inquiry (/Order.aspx?i1=(CDKN1A-6910Z)Recombinant+Zebrafish+CDKN1A) Involved Pathway CDKN1A involved in several pathways and played different roles in them. We selected most pathways CDKN1A participated on our site, such as AKT phosphorylates targets in the cytosol, AMPK signaling, Adaptive Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with CDKN1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site. Pathway Name Pathway Related Protein AKT phosphorylates targets in the cytosol CHUK; CDKN1A; AKT3; CDKN1B AMPK signaling ADRa1A; CPT1B; CPT1A; PPARGC1B; LOC729991; EIF4EBP1; EEF2; INS-IGF2; SLC2A4RG; CAMKK2 Adaptive Immune System ASB8; CXADR; CD300LD; KLRG1; RNF41; DZIP3; TREML4; PDPK1A; CLEC2D; CTS7 Adipogenesis NAMPT; CFD; NDN; AHR; CELF1; BMP3; MEF2B; MBNL1; KLF6A; E2F1 AhR pathway AHR; JUND; NQO1; AHRR; EGFR; CYP1B1; CYP1A1; PTGES3; CDKN1A; JUN Alpha6-Beta4 Integrin Signaling Pathway EIF4EB; RTKN; CD151L; EIF4E; SMAD3B; YWHAQ; DST; CD151; MST1R; NTN1A Androgen receptor signaling pathway KDM1A; MYST2; EGFR; AES; PNRC1; NR0B2A; CARM1; RNF6; RNF14; RANBP9 Angiopoietin receptor Tie2-mediated signaling ELF1; AGTR1; GRB7; ELF2; DOK2; GRB14; CDKN1A; CRK; BMX https://www.creativebiomart.net/symbolsearch_CDKN1A.htm 3/5

  4. 2020/3/28 Protein Function cdkn1a Protein, cyclin-dependent kinase inhibitor 1A (p21, Cip1) - Creative BioMart CDKN1A has several biochemical functions, for example, cyclin binding, cyclin-dependent protein kinase activating kinase activity, cyclin-dependent protein serine/threonine kinase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CDKN1A itself. We selected most functions CDKN1A had, and list some proteins which have the same functions with CDKN1A. You can find most of the proteins on our site. Function Related Protein Function cyclin binding Related Protein USP2; CDK5RAP3; CUL3; CDKN1A; CDK12; CDK4; CDK13; INCA1; MDFIC; CDK6 Function cyclin-dependent protein kinase activating kinase activity Related Protein CDKN1A; ALPK2 Function cyclin-dependent protein serine/threonine kinase inhibitor activity Related Protein KAT2B; CDKN2D; CDKN1B; INCA1; HEXIM1; CDKN1C; CDKN2C; CDKN1BB; CDKN2A; CDKN1A Function metal ion binding Related Protein STK25; RHO; FIBCD1; IHHB; FCER2; SALL1; PVALB2; ZNF563; RRM2B; ZKSCAN3 Function protein binding Related Protein ZFP335; FAM212A; KCNMA1; LRCH1; INO80E; ZNF747; BATF2; NAA10; SMAD9; FBXL12 Function protein complex binding Related Protein AP2A2; HADHA; RBM10; TUB; PPP2R2A; KHDRBS1; NFKBIA; Ctsl; SH2B3; CTSL2 Function ubiquitin protein ligase binding Related Protein PRDX6; C10orf46; BAG5; PTPN22; TXNIP; AICDA; ARIH1; CDC34; UBE2G1; PER3 Interacting Protein CDKN1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull- down and so on. We selected proteins and molecules interacted with CDKN1A here. Most of them are supplied by our site. Hope this information will be useful for your research of CDKN1A. CDK2; PCNA CDKN1A Related Articles Chen, TC; Lin, KT; et al. Using an in Situ Proximity Ligation Assay to Systematically Profile Endogenous Protein-Protein Interactions in a Pathway Network. JOURNAL OF PROTEOME RESEARCH 13:5339-5346(2014). Atsaves, V; Lekakis, L; et al. The oncogenic JUNB/CD30 axis contributes to cell cycle deregulation in ALK plus anaplastic large cell lymphoma. BRITISH JOURNAL OF HAEMATOLOGY 167:514-523(2014).   45-1 Ramsey Road, Shirley, NY 11967, USA   USA: 1-631-559-9269    1-516-512-3133   Europe: 44-203-287-8296   Fax: 1-631-938-8127   Email: info@creative-biomart.com (mailto:info@creative-biomart.com) Enter your email here to subscribe. https://www.creativebiomart.net/symbolsearch_CDKN1A.htm 4/5

  5. 2020/3/28 cdkn1a Protein, cyclin-dependent kinase inhibitor 1A (p21, Cip1) - Creative BioMart Your email address here submit Easy access to products and services you need from our library via powerful searching tools. Copyright © 2007 - 2020 Creative BioMart (/). All Rights Reserved. (https://twitter.com/CreaBiomart) (http://www.facebook.com/pages/Creative-Biomart/374357745946387) (http://www.linkedin.com/company/creative-biomart) (/blog/) https://www.creativebiomart.net/symbolsearch_CDKN1A.htm 5/5

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