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Polycythemia Vera diagnosis is usually carried in the average age of people 60u201365 years. It is uncommon in people under the age of 40. PV develops more often in men than in women. Most people with PV do not have a family history of this disease. Mutation in the JAK2 kinase is responsible for PV. Most cases of PV are associated with genetic changes that are somatic, not in the egg and sperm cells, which pass on genetic information to offspring.<br> <br>Enlargement of the spleen sometimes cause pain and problem to the patients, and for that surgery is done to remove the spleen (Splenectomy). No single
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