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  1. What is Methadone?  Methadone is a generic medication developed in Germany from 1937 to 1939. It was approved in the USA in 1947 for medical use.  Methadone is also on the List of Essential Medicines by World Health Organization, which contains only those medicines that are safe and the most effective medications needed in the health system.  Methadone comes in several formulations such as a tablet, dispersible tablet, solution, and concentrated solution. It also comes in injection only for administration by doctors.

  2. What is Methadone Used To Treat?  Methadone is an opiate used in the treatment of opioid maintenance in opioid dependence and chronic pain.  Methadone detoxifies in opioid dependence in less than a month. A single dose of the medication has a rapid effect, and it reaches its maximum effectiveness within five days of use.  Pain-relieving effects of Methadone starts as soon as 20 to 30 minutes after a single dose and last for about six hours. After a long term use of Methadone, pain relief lasts for 8 to 36 hours in people with normal liver functioning.

  3. Methadone Maintenance  Methadone helps treat opioid use disorder. It is useful both as maintenance therapy or a short period detoxification for managing opioid withdrawal symptoms.  Methadone treatment programs for opioid maintenance or detoxification ranges from a few months to several years.  The main goals of maintenance are to suppress the abstinence syndrome, relieve opioid cravings, and block the euphoric effects of opioids.

  4. Opioid Detoxification  Methadone is an approved medication for the treatment of opioid addiction in many parts of the world, including America.  The use of Methadone for treating addiction is strictly regulated. Outpatient treatment plans must be certified by the federal Substance Abuse and Mental Health Services Administration (SAMHSA) and registered by the DEA (Drug Enforcement Administration) in the USA.

  5. Pain  Methadone is a useful analgesic in chronic pain.  Methadone is active at the NMDA receptor that makes it more useful for neuropathic pain. Due to the same reason, Methadone tolerance effects are less than that of other opioid analgesics.

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