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Electroneurophysiology procedure introduction for Physiotherapists, DPT graduates
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MS PT Lecture# 5-A Introduction to Neurophysiology Neurophysiology Neurophysiology Neurophysiology Procedures Procedures Procedures Procedures By: Dr.Chaman Lal PT B.S.PT, PPDPT (M.Phil Physiotherapy), MPH (M.Phil Public Health), Master in Physical Education & Sports Injuries (UOS), Dip. in sports Injuries, PG in Clinical Electroneurophysiology (AKUH), Registered.EEGT (USA), Member of ABRET, AANEM & ASET (USA), MPPS(PAK), MPPTA(PAK), PhD Physiotherapy Scholar (Malaysia).
OUTLINES ? Neurophysiology ? Neurophysiology Disciplines & Test Procedures ? Biological Signals / Activity ? Electromyography & Nerve Conduction Studies (EMG &NCS) ? Electroenphalogram Test (EEG) ? Brainstem Evoked Response Audiometry (BERA) ? Visual Evoked Potential Studies (VEP) ? Somatosensory Evoked Potential(SSEP) ? Transcranial Magnetic Stimulation (TMS) ? Neurophysiologic Intraoperative Monitoring (NIOM) ? Split Night Polysomnography (SPSG) Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
N E U R O P H Y S I O L O G Y ? Neurophysiology is a science of medical specialty that studies the central and peripheral nervous systems through the recording of bioelectrical activity, whether spontaneous or stimulated. ? These bioelectrical signals are gathered with differential amplifier studied. help of be to Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
NEUROPHYSIOLOGY STUDY DISCIPLINES E E G E M G & N C S B E R A V E P SPSG SSEP TMS NIOM Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
BIOLOGICAL SIGNALS ? PART I : What makes nerve cells excitable? ? Spontaneous electrical activity-EEG ? Establishment of the membrane potential ? Ion channels ? Generation of action potential and saltatory conduction ? PART II: How do nerve cells communicate with each other? ? Synaptic transmission (central versus peripheral) ? Neuromuscular junction ? PART III: Result of synaptic Transmission ? Clinical relevance Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
Electroencephalogram EEG Electroencephalogram is the record of the spontaneous Excitatory & Inhibitory Postsynaptic potentials on Electroencephalograph (paper) by using Electroencephalography Technique. Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
ELECTROMYOGRAPHY & NERVE CONDUCTION STUDY ? Electromyography is the study of motor unit action potentials via disposable needle electrodes to check either spontaneous activity or after active muscle activation /stimulation. ? Nerve conduction study is the study of the Action Nerve conduction study is the study of the Action Potential recorded from distribution) or Muscle belly after giving appropriate stimulation. skin (Cutaneous-Sensory ? Both test parts are studied together for final conclusion or diagnosis of the neuromuscular disease process. Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
7thNational Paediatric Neurology Conference Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
Membrane Potential Refers to the potential difference across the neuronal cell membrane ? Resting potential is usually between -60 to -70mV with net negative inside the membrane ? Membrane potential results from the separation of charge across the cell membrane ? Results from the unequal distribution of intracellular and extracellular ions ? Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
STIMULATION OF MEDIAN MOTOR NERVE Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
SALTATORY PROPAGATION OF ACTION POTENTIAL Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
Generation of Action Potential Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
ACTION POTENTIAL Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
BRAINSTEM EVOKED RESPONSE AUDIOMETRY (BERA) Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
THRESHOLD RESPONSE Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
VISUAL EVOKED POTENTIALS STUDY (VEP) Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
SOMATOSENSORY EVOKED POTENTIALS STUDY (SSEP) Introduction to Neurophysiology Procedures by Dr Chaman Lal PT 10/27/2018
References “Electromyography and Neuromuscular Disorders:Clinical–Electrophysiologic Correlations “ 3RDED., David C. Preston, MD; Barbara E. Shapiro, MD, PhD ? Kandel ER, Schwartz JH and Jessell TM (1991) Principles of Neural Science. Third Edition. Chapters 5-11, 65. ? Alberts B, Bray D, Lewis J, Raff M, Roberts K and Watson JD (1994) Molecular Biology of the cell. Third Edition. Chapter 11. ? Cooke SF and Bliss TVP (2006) Plasticity in the human central nervous system. Brain 129, 1659–1673. 129, 1659–1673. ? Waxman SG (1998) Demyelinating diseases--new pathological insights, new therapeutic targets. N Engl J Med. 29;338(5):323-5. ? Ito M (2001) Cerebellar Long-Term Depression: Characterization, Signal Transduction, and Functional Roles. Physiological Reviews, Vol. 81, No. 3, July 2001, pp. 1143-1195. ? Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia A, McNamara JO, and Williams SM (2001) Neuroscience. Second Edition. Chapter 25. ? 10/27/2018