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The effects of a Dianabol 10mg of treatment with a potent anabolic steroid, methandienone (5 and 10 mg daily), and a very weak androgen and hormone precursor, dehydroepiandrosterone sulphate (DHEAS, 20 and 40 mg daily) and placebo on plasma testosterone, LH and FSH levels, red cell volume and red cell 2,3-diphosphoglycerate (2,3-DPG) concentration in endurance sportsmen were studied using a double-blind test system. A highly significant decrease in mean plasma testosterone was observed after and Dianabol 10mg methandienone regimen (66 and 73%). Treatment with 40 mg of DHEAS decreased mean testosterone levels by 41% (not statistically significant). Pre-test testosterone levels were reattained about 10 days after the end of the treatment period with the higher doses of both compounds, while 2–6 weeks afterward a significant overcompensation in mean plasma testosterone levels was observed. No significant changes in plasma gonadotropins were seen immediately after treatment with either of these steroids but later a tendency towards decreased FSH and LH levels was observed in the subjects who received the higher doses of both compounds. Methandienone (also referred to as methandrostenolone, Dbol, Dianabol) is an associate orally-effective steroid hormone originally developed in Deutschland and discharged within the USA within the early Sixties by Ciba Specialty Chemicals. This is a by-product of androgenic hormone, one amongst the foremost standard steroid compounds within the world and therefore the second steroid (after testosterone) ever made. Methandienone promotes dramatic will increase in supermolecule synthesis, glycogenolysis, and muscle strength over a short space of time. It also has the effect of decreasing the steroid’s affinity for sex hormone-binding globulin. As a result, methandrostenolone is significantly more active than an equivalent quantity of testosterone, resulting in the rapid growth of muscle tissue.