Vascular Disrupting Agents Market Insights Shared in Detailed Report

1. The process of formation of new blood vessels is called angiogenesis. Angiogenesis is essential for growth and multiplication of solid tumors. If size of the tumor is less than 2 mm3, growth factors and nutrients are supplied by diffusion. However, if the tumor size is larger, blood supply to the tumor needs to be established. Dependence of tumor cells on newly formed blood vessels for their growth and metastasis has resulted in focusing on ‘angiogenesis’ as a novel target for cancer treatment. Read Report Overview - https://www.transparencymarketresearch.com/vascular-disrupting-agents- market.html Vascular disrupting agents is a new and promising class of targeted anticancer agents having antiangiogenic effect. These agents primarily act by disrupting the formed abnormal solid tumor vasculature by targeting the immature dysmorphic endothelial cells. They exert their anticancer effect by targeting new tumor blood vessels that are formed by angiogenesis, blocking the supply of blood to the formed tumor. This makes the tumor deprived of essential nutrients and oxygen, leading to tumor cell death. Vascular disrupting agents are primarily used in the treatment of different types of cancer such as ovarian cancer, thyroid cancer, liver cancer, colorectal cancer, glioblastoma, and renal cell carcinoma. Vascular disrupting agents are of two types: small-molecule and ligand-directed vascular disrupting agents. Small-molecule vascular disrupting agents have been further classified into tubulin-binding agents and flavonoids. Request Brochure of Report - https://www.transparencymarketresearch.com/sample/sample.php?flag=B&rep_id=32492 Tubulin binding agents act by selectively binding to the β-tubulin colchicine binding site, which weakens microtubules and leads to change in the 3-dimensional shape of endothelial cells. Endothelial cells interrupt the tumor blood vessel, thereby leading to necrosis of cancer cells within the tumor. Examples of tubulin-binding agents include combretastatin, crolibulin, verubulin, and fosbretabulin. The other type of small-molecule vascular disrupting agents are flavonoids, which promote localized release of the tumor necrosis factor TNFα from nearby activated macrophage cells. Examples of flavonoids include 5, 6-dimethylxanthenone-4-acetic acid (DMXAA) and icaritin/pexastimogene devacirepvec. Ligand-directed vascular disrupting agents primarily act by delivering toxic effects to tumor endothelium. The small-molecule vascular disrupting agents segment is expected to expand significantly during the forecast period, as a majority of molecules in the pipeline are small molecules. Additionally, high incidence and prevalence rate of cancer, increase in the demand for newer treatment options, and the large number of ongoing clinical trials boost the vascular disrupting agents market. However, unsatisfactory results of clinical trials and low availability of safety data restrain the vascular disrupting agents market. Request for TOC @ https://www.transparencymarketresearch.com/sample/sample.php?flag=T&rep_id=32492 In terms of geography, the global vascular disrupting agents market has been segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America leads the global

2. market, followed by Europe. Growth of the market in North America is attributable to high incidence and prevalence rate of cancer, rise in the geriatric population, and increase in the demand for advance treatment options in the region. Asia Pacific is an emerging market for vascular disrupting agents, due to developing health care infrastructure, increasing patient awareness, and rising government expenditure on health care in the region. However, low awareness among patients, high cost of therapy, and lack of availability of treatment options are factors restraining the vascular disrupting agents market in regions such as Middle East & Africa and Latin America. Pre Book Vascular Disrupting Agents Market Report at https://www.transparencymarketresearch.com/checkout.php?rep_id=32492&ltype=S Major players operating in the global vascular disrupting agents market include Mateon Therapeutics, Immune Pharmaceuticals, Nereus Pharmaceuticals, Madrigal Pharmaceuticals, Inc., Celgene Corporation, Bionomics Ltd., and Lees Pharmaceutical Holdings. More Trending Reports by Transparency Market Research – Atherectomy Devices Market: https://www.biospace.com/article/atherectomy-devices-market- technological-advancements-to-propel-market/ Vessel Sealing Devices Market: https://www.prnewswire.com/news-releases/massive-rise-in-surgical- procedures-around-the-world-to-boost-growth-of-vessel-sealing-devices-market-between-2018-and- 2026-tmr-301185572.html About Us Transparency Market Research is a global market intelligence company, providing global business information reports and services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insight for thousands of decision makers. Our experienced team of Analysts, Researchers, and Consultants, use proprietary data sources and various tools and techniques to gather, and analyse information. Now avail flexible Research Subscriptions, and access Research multi-format through downloadable databooks, infographics, charts, interactive playbook for data visualization and full reports through MarketNgage, the unified market intelligence engine. Sign Up for a 7 day free trial! Contact Transparency Market Research, 90 State Street, Suite 700, Albany, NY 12207 Tel: +1-518-618-1030 USA - Canada Toll Free: 866-552-3453 Website: https://www.transparencymarketresearch.com/