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Welcome to Immunology Course

Welcome to Immunology Course. IMMUNOLOGY. Prof. dr Vera Pravica Prof. dr Dušan Popadić Doc. dr Miloš Marković Assist. dr Emina Savić imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic. Advice. for successful learning and passing the exam . Immunology.

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Welcome to Immunology Course

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  1. Welcome to Immunology Course

  2. IMMUNOLOGY Prof. dr Vera Pravica Prof. dr Dušan Popadić Doc. dr Miloš Marković Assist. dr Emina Savić imunologija@med.bg.ac.rs Tel. 3643-236 Facebook: Antitelija Limfocitic

  3. Advice • for successful learning • and passing the exam

  4. Immunology • independent subject (separated from Microbiology) • winter semester • 45 hours during 15 week Seminars (20) Lectures (15) Labs (10)

  5. Seminars,Labsand Lectures are integral parts of the course Student are allowed to be absent on seminar or lab twice during the semester

  6. Textbook • Basic Immunology: Functions andDisordersof the Immune System • Authors: Abbas AK, Lichtman AH. • Publisher:Elsevier • 3rd edition updated, 2011 .ppt presentationsand authorised supplementary material (available on web site)

  7. Continuous assessment Activity during the course (seminars, labs and lectures) through activity points Presence on lectures noted separately Colloquium – divided in three separate mini-tests after every4 weeks (5th, 9th and 13th week) Final test

  8. Colloquium Test (multiple choice – 1 correct answer out of 4) It consists of 30 questions in total (divided into 3 mini tests with 10 questions each) • first: in the 5th week (first 4 chapters from the textbook) • second: in the 9th week (chapters 5 to 8) • third: in the 13th week (chapters 9 to 12 plus immunological methods and vaccines) 1 point for each correct answer (max 30 points) 15 minutes per mini test

  9. Final test • 70 points in total • consists of: • 20 multiple choice questions with one correct answer out of four • (2 points for each correct answer, max. 40 points) • 5 fill-in questions where correct word should be filled in the blanks • (max. 20 points) • 2 questions that require short answers up to five sentences • (max. 10 points) Threshold for passing the final test is 36 points (50% plus 1)

  10. Final mark in Immunology For the passing of the Immunology exam the minimum of 51 points (out of 100) should be collected on condition that the 50% of points plus one (minimally 36) has been reached in the final test Note: If the student collected less than 15 points in colloqium (i.e. 50%), he/she must perform better than 36 in the final test 100 points in total 51-60 6 (six) 61-70 7 (seven) 71-80 8 (eight) 81-90 9 (nine) 91-100 10 (ten) Activity points (max. 10 points) are added only if the minimum of 51 points has been reached

  11. Introduction to immune system • Innate and adaptive immunity • Types of adaptive immunity • Properties and phases of adaptive immune response • Central and peripheral lymphoid organs • Lymphocyte recirculation

  12. ADAPTIVE (Aquired) INNATE (Natural) (Native) IMMUNITY

  13. Principle mechanisms of innate and adaptive immunity

  14. Principle mechanisms of innate and adaptive immunity

  15. The most important cells of the immune system

  16. Chain of events in infection

  17. Pathogen(s) enter(s) tissue

  18. Pathogen(s) enter(s) tissue

  19. Pathogen(s) enter(s) tissue

  20. Macrophages recognize (and eliminate) pathogens

  21. Macrophages recognize (and eliminate) pathogens

  22. Macrophages recognize (and eliminate) pathogens

  23. Inflammation is induced and PMNs attracted

  24. Inflammation is induced and PMNs attracted

  25. Antigen-presenting cells (APCs) capture antigen(s)

  26. Antigen-presenting cells (APCs) capture antigen(s)

  27. APCs migrate to draining lymph node

  28. APCs migrate to draining lymph node

  29. APCs migrate to draining lymph node

  30. APCs migrate to draining lymph node

  31. APCs migrate to draining lymph node

  32. APCs migrate to draining lymph node

  33. APCs migrate to draining lymph node

  34. APCs migrate to draining lymph node

  35. APCs migrate to draining lymph node

  36. T cells are activated by APCs

  37. T cells are activated by APCs

  38. T cells are activated by APCs

  39. B cell are activated (helped by T cells)

  40. B cell are activated (helped by T cells)

  41. B cell are activated (helped by T cells)

  42. Activated B cells (plasma cells) produce antibodies (Abs)

  43. Activated B cells (plasma cells) produce antibodies (Abs)

  44. Activated B cells (plasma cells) produce antibodies (Abs)

  45. Activated B cells (plasma cells) produce antibodies (Abs)

  46. Activated T cellsandAbsleave lymph node...

  47. ... enter blood stream and...

  48. ... enter blood stream and...

  49. ... migrate to site of infection

  50. ... migrate to site of infection

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