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Bell Work

Bell Work. If a mother who has type A- blood produces a child with type B+ blood, what must the genotype of father be?. Recap. On “Whodunit?” Lab. Recap. On “Whodunit?” Lab. Results: Mrs. Sanders (A): A+ Billy Joe (B): B+ John Deer (C): AB- Jane Lame (D): O+ Crime Scene: O+.

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Bell Work

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  1. Bell Work • If a mother who has type A- blood produces a child with type B+ blood, what must the genotype of father be?

  2. Recap. On “Whodunit?” Lab

  3. Recap. On “Whodunit?” Lab Results: Mrs. Sanders (A): A+ Billy Joe (B): B+ John Deer (C): AB- Jane Lame (D): O+ Crime Scene: O+

  4. Discussion ?s • How would you respond to the burglar’s denial? • What antigens are on the burglar’s blood? • What antibodies are present on the burglar’s blood? • How can you determine if a blood sample is compatible to transfuse from one individual to another in an emergency situation?

  5. Sex-Linked Inheritance • Sex linked gene: a gene located on a sex chromosome • Genes found on the Y chromosome are found only in males and are passed from father to son • Genes found on the X chromosome are found in both sexes and can be passed from either parent • Although X-linked diseases can occur in both sexes, they usually occur in males (males only have one X chromosome)

  6. Sex linked Traits Recessive Dominant • Also called X-linked recessive • Occurs when both matching genes on the x chromosome are abnormal to produce disease. • If only one X chromosome is affected in a female, the disease does not show up • If the X chromosome in a male is abnormal, the male will show the disorder • Also called X-linked dominant or Y-linked dominant • Occurs when the abnormal gene dominants (even when the matching gene from the other parent is normal).

  7. Sex linked Traits Recessive Dominant • Examples • Androgen Insensitivity Syndrome • Color Blindness • Fragile X syndrome • Hemophilia • Muscular Dystrophy • X-linked anhidrotic dysplasia • Examples • Alport’s Syndrome • Aarskog’s Syndrome • Coffin-Lowry Syndrome (CLS) • Rett Syndrome (RS)

  8. Red-Green Color Blindness- found on the X chromosome • Presence in the Phenotype • For this recessive allele to be expressed in females, it must be present in two copies on both X chromosomes (thus it is recessive) • To be expressed in males, it only needs to be present on the X chromosome

  9. How a normal person might seem a picture. How a colorblind person might see the same picture.  The green grass and the red flag stripes appear to be the same color, as do the greenish-blue sky and the reddish-blue flagpole.

  10. Color Blindness • A female who carries the gene for color blindness mates with a man who is not color blind. How many of their offspring will be carriers of color blindness? How many of their children will be color blind? X’ X X Y

  11. Muscular Dystrophy • Show the potential offspring for a given birth, if the mother is a carrier (only one abnormal X chromosome) and the father is normal: • 25% chance of a normal boy • 25% chance of a boy with disease • 25% chance of a normal girl • 25% chance of a carrier girl without disease • If the father has the disease and the mother is normal: • 100% chance of a normal boy • 100% chance of a carrier girl without disease X’ X X Y

  12. Muscular Dystrophy • If the father has the disease and the mother is normal: • 100% chance of a normal boy • 100% chance of a carrier girl without disease X X X’ Y

  13. Hemophilia X’ X X Y • Hemophilia is an X-linked recessive trait, if a woman who is heterozygous for the trait (meaning she is a carrier) marries a man who does not have the disorder, what percentage of their offspring would be affected by the disease? What percent would be carriers for the disease?

  14. Bell Work Are sex linked traits more common in males or females? Why?

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