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Chem 509 Signal Transduction Winter 2012 PowerPoint PPT Presentation


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Chem 509 Signal Transduction Winter 2012. Lecture 2. What difference between Gs, Gq and Gi?: Gs, G protein that is stimulatory and binds AC Gq, G protein that is stimulatory and binds PLC Gi, G protein that is inhibitory and binds AC. Phosphatidylinositol. Phosphatidylinositol-diphosphate.

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Chem 509 Signal Transduction Winter 2012

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Chem 509 signal transduction winter 2012

  • Chem 509

  • Signal Transduction

  • Winter 2012

Lecture 2


Chem 509 signal transduction winter 2012

  • What difference between Gs, Gq and Gi?:

  • Gs, G protein that is stimulatory and binds AC

  • Gq, G protein that is stimulatory and binds PLC

  • Gi, G protein that is inhibitory and binds AC.


Chem 509 signal transduction winter 2012

  • Phosphatidylinositol

Phosphatidylinositol-diphosphate


Chem 509 signal transduction winter 2012

  • Phospholipases

Phospholipase A1-can hydrolyze the sn-1 acyl bond but can also

hydrolyse the sn-2 acyl bond. In the former case, this

liberates a fatty acid and 2-acyl-glycerophospholipid.


Chem 509 signal transduction winter 2012

  • Phospholipases

Phospholipase A­2-hydrolyzes the sn-2 acyl bond.

This liberates a fatty acid and a lysophospholipid

(1-acyl-glycerophospholipid)


Chem 509 signal transduction winter 2012

  • Phospholipases

Phospholipase C-hydrolyzes one phosphoester bond to generate

diacyglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).


Chem 509 signal transduction winter 2012

  • Phospholipases

Phospholipase D-will hydrolyse the other phosphoester bond to generate

phosphatidic acid (amphiphilic product) and

inositol 4,5 diphosphate (IP2).


Chem 509 signal transduction winter 2012

PI=Phosphatidylinositol, Phosphorylated derivatives of PI are denoted as PIPx.

PC=Phosphatidylcholine

PA=Phosphatidic acid

Lyso PC= deacylated phosphatidylcholine


Chem 509 signal transduction winter 2012

Calmodulin


Chem 509 signal transduction winter 2012

  • End of GPCR lecture story

  • Begin insulin signaling story


Chem 509 signal transduction winter 2012

Insulin signaling


Chem 509 signal transduction winter 2012

Insulin signaling


Chem 509 signal transduction winter 2012

  • Other Receptor Tyrosine Kinase Receptors


Chem 509 signal transduction winter 2012

Adaptation of insulin-mediated growth signal


Chem 509 signal transduction winter 2012

  • Brief overview of cancer signaling pathways


Chem 509 signal transduction winter 2012

Cell cycle


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