Chem 509 Signal Transduction Winter 2012. Lecture 2. What difference between Gs, Gq and Gi?: Gs, G protein that is stimulatory and binds AC Gq, G protein that is stimulatory and binds PLC Gi, G protein that is inhibitory and binds AC. Phosphatidylinositol. Phosphatidylinositol-diphosphate.
Phospholipase A1-can hydrolyze the sn-1 acyl bond but can also
hydrolyse the sn-2 acyl bond. In the former case, this
liberates a fatty acid and 2-acyl-glycerophospholipid.
Phospholipase A2-hydrolyzes the sn-2 acyl bond.
This liberates a fatty acid and a lysophospholipid
Phospholipase C-hydrolyzes one phosphoester bond to generate
diacyglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3).
Phospholipase D-will hydrolyse the other phosphoester bond to generate
phosphatidic acid (amphiphilic product) and
inositol 4,5 diphosphate (IP2).
PI=Phosphatidylinositol, Phosphorylated derivatives of PI are denoted as PIPx.
Lyso PC= deacylated phosphatidylcholine
Adaptation of insulin-mediated growth signal