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Concentric Ring Electrodes and Epilepsy

BME 482 Kevin Sylvestre. Concentric Ring Electrodes and Epilepsy. Intractable Seizures. Seizures which are difficult to control, despite treatment Often must resort to invasive brain surgery to treat Very dangerous, can lead to status epilepticus (SE)

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Concentric Ring Electrodes and Epilepsy

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  1. BME 482 Kevin Sylvestre Concentric Ring Electrodes and Epilepsy

  2. Intractable Seizures • Seizures which are difficult to control, despite treatment • Often must resort to invasive brain surgery to treat • Very dangerous, can lead to status epilepticus (SE) • Persistent seizure, 20% mortality rate, often result in permanent damage

  3. TcES • If SE is interrupted and eliminated, this constitutes cure • One method: transcutaneous electrical stimulation (TcES) • Utilizes tripolar concentric ring electrodes, developed by Dr. Walter Besio (currently of URI BME)

  4. Concentric Ring Electrodes • High spatial resolution thanks to unique configuration • Desirable in epileptic diagnosis • Potentially useful for epileptic treatment

  5. Effect on Epilepsy • Experiment in 2007: • 16 rats (8 control, 8 experimental) • All have pilocarpine-induced seizures with SE • Experimental given TcES • Result: • Experimental group returned to baseline activity after 1-3 applications of TcES, most survived • Control group expired after average of 15 hours

  6. Other Observations • No tonic contractions, aversion responses or escape behavior elicited by rats • Rats went about business normally, even during TcES • Most likely indicates painlessness • TES often induces negative reactions • Leaves rats gasping and incapacitated

  7. References • Besio W., Koka K., Cole A., “Feasibility of Non-invasive Transcutaneous Electrical Stimulation for Modulating Pilocarpine-induced Status Epilepticus Seizures in Rats,” Accepted by Epilepsia, 4/18/2007.  IF 3.55 • Besio W., Koka K., Aakula R., Dai W., “Tri-polar Concentric Ring Electrode Development for Laplacian Electroencephalography,” IEEE Trans BME, Vol. 53, No. 5, pp. 926-933, 2006. IF 1.6 • Status epilepticus. (2010, March 13). In Wikipedia, The Free Encyclopedia. Retrieved 18:09, April 4, 2010, from http://en.wikipedia.org/w/index.php?title=Status_epilepticus&oldid=349535889

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