TRTRE

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?????(?)??????????????????????????????????????????????????????????????(HeLaTR)????????. . . . . . . . . . . . 1. 2. 3. 4. 5. Luciferase activity(fold induction). T3. -. . . -. . DR4. DR0. ????????????(T3)??????????????????(DR4)??????????????????????(????)????DNA??????????????????????????????????
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TRTRE

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1. 1.(?)?????????????????????????? 2.?????????(?)????????????? 3.????????????????????????? ?????????????????????????????????? ??????????????????????????????? ????????????? ????????????????????????????????????? ???3????????????????? * ?????

2. ??????????????????????????????????????????????????(TR)????????????????(TRE)?????????????????????????????????? TRE TR RXR TATA No TF General TFs TRE TR RXR TATA Transcription General TFs Coactivators Corepressors mRNA protein Nucleus Cytoplasm ??????? ???? ???????????????????????????????????????? * ????????????????????

3. ?????(?)??????????????????????????????????????????????????????????????(HeLaTR)???????? 1 2 3 4 5 Luciferase activity (fold induction) T3 - + - + DR4 DR0 ????????????(T3)??????????????????(DR4)??????????????????????(????)? ???DNA????????????????????????????????????????????????????? CMV-P HsTRa1 cDNA TRE SV40-P Luciferase cDNA T3 TR TRE Luciferase TRE DR4: AGGTCANNNNAGGTCA DR0: AGGTCAAGGTCA Reporter HeLa HeLaTR * ??????????????????

4. ???????A(BPA)?????(DEHP)???????(TCDD)? ???PCB(PCB-OH)? ???????????????????????????????????? ????????????????????????????????????????? HeLaTR with DR4-SV40-Luc T3 +/- endocrine disrupting chemicals Luciferase activity ????????????????????????????????????? DNA????????????????????????????????????? ???????????????????????????????????????? ????????? * ??????????

5. ?????? HeLaTR???????(?)??????????? ???????????????????????? ???Drs.?&??????? ??????????????????????? * (?)?????????????????????????

6. TRE TATA General TFs Coactivators T3 RXR TR Transcription mRNA 4-1BB TRAF1 Caspase Activity Apoptosis TRAF2 DNA???????????????????????????????4-1BB???????????4-1BB??????????????????????????????????????? ???????????? ????????? ???????????? ?????????? * ?????????????????????????

7. ???????????????????????????????? Yamada-Okabe, T., Satoh, Y. and Yamada-Okabe, H. (2003) Thyroid hormone induces the expression of 4-1BB and activation of caspases in a thyroid hormone receptor dependent manner. Eur. J. Biochem. 270: 3064-3073. Yamada-Okabe, T., Aono, T., Sakai, H., Kashima, Y. and Yamada-Okabe, H. (2004) 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol. Appl. Pharmacol. 194:201-210. * ????

8. ?????? 1.???????????(?)?????????????????????????????? 2.?????????????????????????????????????????????????????????? * ???? Home What's New Introduction Research Staff Contact Publications Link



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