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Novel Technologies to assess Gut Health Claims for Carbohydrates subtheme: Immunobarrier Paul de Vos (UMCG) [email protected] Design a technology platform: to assess health benefits that meet EFSA requirement. Carbohydrates.

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Novel Technologies to assess Gut Health Claims for Carbohydrates subtheme:ImmunobarrierPaul de Vos (UMCG)[email protected]

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Design a technology platform: to assess health benefits that meet EFSA requirement

Food enhanced stimulation of

epithelial barrier

Immunemodulatory

Food components

Delivery and uptake of fragile

vitamines, carbohydrates,

fibers etc

Food components

Stimulating specific

immunity/memory

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Design a technology platform: to assess health benefits that meet EFSA requirement

1. HTP screening to identify immunemodulating

carbohydrates and get insight in stage/mechanism

of effect.

2. Testing in appropriate animal model

(eg vaccination, allergy, Th1 and Th2 etc)

Identification of specific effect:

(i) Immune stimulation/suppressing/regulatory

(ii) Beneficial for adults, infants, diseased or

healthy subjects, male or female

Successful compounds will enter subtheme

human studies (healthy/adults/infants)

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Design a technology platform: to assess health benefits that meet EFSA requirement

1. HTP screening to identify immunemodulating

carbohydrates and get insight in stage/mechanism

of effect.

Assays to measure effect on mucus production/function,

Assays to measure effect on gut epithelium (permeability, defensins etc)

Assays to measure effect on lymphocytes/dendritics

Assays to identify effects on pattern recognition receptors

 Combined leads to insight how and where carbohydrates work

2. Testing in appropriate animal model

Based on results of 1. in depth analysis on mechanisms in experimental

animal studies

Vaccination, Pseudomonas, RSV, Rota, influenza, Listeria monoc., Trichinella Spiralis infection models, Allergy models (cow’s milk, henns egg, peanut allergy), DTH models, autoimmune diabetes models, asthma models, COPD models, cachexia models, inflammation models, arthritis (OA)/RA models

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Design a technology platform: to assess health benefits that meet EFSA requirement

H. Wichers

H. Schmidt

H. Savelkoul

J. Dekker

J. Mes

H. Schols

...........

P. de Vos

M.M. Faas

H.J. Verkade

M. Priebe

...........

J. Garssen

...........

(expertise: HTP systems, animals models)

Other contributing institutes/companies and participants welcome !

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