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TIMIC. Majority in IS therapy arm showed an ↑ in LVEF (26.54-45.6%) and ↓ in LVEDD (68.4-54.4 mm) No patients in placebo arm improved; some showed further ↓ in LVEF and ↑ in LVEDD No CV death or transplant at 6 months in both arms. (p < 0.001).

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Timic
TIMIC

Majority in IS therapy arm showed an ↑ in LVEF (26.54-45.6%) and ↓ in LVEDD (68.4-54.4 mm)

No patients in placebo arm improved; some showed further ↓ in LVEF and ↑ in LVEDD

No CV death or transplant at 6 months in both arms

(p < 0.001)

Trial design: Patients with virus-negative inflammatory cardiomyopathy were randomized to either immunosuppressive (IS) therapy with prednisone and azathioprine or placebo for 6 months. Echocardiographic parameters were compared at 6 months.

Results

30

19.1

15

-6.4

Conclusions

%

0

  • IS therapy in virus-negative inflammatory cardiomyopathy may be associated with an improvement in LVEF and LVEDD, compared with placebo

  • Further corroboration is necessary

  • May represent novel approach to HF management in these patients

-15

Change in LVEF from baseline

IS therapy

(n = 43)

Placebo

(n = 42)

Frustaci A, et al. Eur Heart J 2009;Jun 25:[Epub]