Overview of seizures and epilepsy
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Overview of Seizures and Epilepsy. Lucyna Zawadzki, MD Director of Pediatric Epilepsy Program UWHC Madison. Learning Objectives. 1. After completing this activity, the learner will be able to define current prevalence and trends related to epilepsy and seizures.

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Overview of Seizures and Epilepsy

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Overview of seizures and epilepsy

Overview of Seizures and Epilepsy

Lucyna Zawadzki, MD

Director of Pediatric Epilepsy Program

UWHC Madison


Learning objectives

Learning Objectives

  • 1. After completing this activity, the learner will be able to define current prevalence and trends related to epilepsy and seizures.

  • 2. After completing this activity, the learner will be able to describe current treatments-including alternative care and new methods of drug delivery for children and adolescents with epilepsy.

  • 3. After completing this activity, the learner will be able to propose a plan of care for a student with epilepsy, including activity restrictions.

  • 4. After completing this activity, the learner will be able to describe and implement effective strategies for communicating and collaborating with health care providers around care for students with epilepsy.


Definitions

Definitions

  • Epileptic seizure- a transient occurrence of signs and/or symptoms due to abnormal excessive pattern of excitability and synchrony among neurons in select brain areas.

  • Epilepsy- persistent epileptogenic abnormality of the brain that is able to spontaneously generate paroxysmal activity

    • Recurrent seizures (two or more)which are not provoked by systemic or acute neurologic insults

  • Epilepsy syndrome- complex of signs and symptoms that define a unique epileptic condition


Epilepsy facts

Epilepsy Facts

  • 1 in 26 people will develop epilepsy during their lifetime

  • More common then autism, cerebral palsy, MS and Parkinson’s disease combined

  • Epilepsy accounts for 1% of the global burden of disease ( WHO), equal to burden of lung ca in men and breast ca in women


Risk of epilepsy

Risk of Epilepsy

  • Highest at extremes of life ( 1st year of life and in elderly)

  • Risk of having at least 1 seizure in lifetime is 10%, and 1/3 will develop epilepsy

  • 2.2 mln of Americans

  • 65 mln people worldwide


Incidence and prevalence in pediatric population

Incidence and Prevalence in Pediatric Population

  • 5 per 1000 in school-aged children

  • 1.5 per 1000 in preschool-aged children

  • Affects more then 300,000 children under age 15

  • >90,000 not adequately treated


Seizure classification

Seizure Classification

  • International League Against Epilepsy (ILAE) 2010 revised classification

  • Based on known causes of epilepsy:

    • Genetic

    • Structural/metabolic

    • Unknown cause


Generalized seizures

Generalized Seizures

Tonic–clonic (in any combination)

Absence

Typical

Atypical

Absence with special features

Myoclonic absence

Eyelid myoclonia

Myoclonic

Myoclonic

Myoclonic atonic

Myoclonic tonic

Clonic

Tonic

Atonic


Focal seizures

Focal Seizures

  • Without impairment of consciousness or awareness

  • With observable motor or autonomic components. This roughly corresponds to the concept of “simple partial seizure.

  • Involving subjective sensory or psychic phenomena only. This corresponds to the concept of an aura.

  • With impairment of consciousness or awareness (dyscognitive). This roughly corresponds to the concept of complex partial seizure.

  • Evolving to a bilateral, convulsive seizure (involving tonic, clonic, or tonic and clonic components). This expression replaces the term “secondarily generalized seizure.”


Epileptic syndromes

Epileptic Syndromes

  • Defined by:

    • Clinical features

    • Seizure type(s)

    • Age of onset

    • Family history

    • EEG findings

    • Diagnostic Investigations

    • Treatment

    • Prognosis


Electroclinical syndromes arranged by age at onset

Electroclinical syndromes arranged by age at onset

Neonatal period

Benign familial neonatal epilepsy (BFNE)

Early myoclonic encephalopathy (EME)

Ohtahara syndrome

Infancy

Epilepsy of infancy with migrating focal seizures

West syndrome

Myoclonic epilepsy in infancy (MEI)

Benign infantile epilepsy

Benign familial infantile epilepsy

Dravet syndrome

Myoclonic encephalopathy in nonprogressive disorders


Overview of seizures and epilepsy

  • Childhood

  • Febrile seizures plus (FS+) (can start in infancy)

  • Panayiotopoulos syndrome

  • Epilepsy with myoclonic atonic (previously astatic) seizures

  • Benign epilepsy with centrotemporal spikes (BECTS)

  • Autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE)

  • Late onset childhood occipital epilepsy (Gastaut type)

  • Epilepsy with myoclonic absences

  • Lennox-Gastaut syndrome

  • Epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS)

  • Landau-Kleffner syndrome (LKS)

  • Childhood absence epilepsy (CAE)


Overview of seizures and epilepsy

  • Adolescence – Adult

  • Juvenile absence epilepsy (JAE)

  • Juvenile myoclonic epilepsy (JME)

  • Epilepsy with generalized tonic–clonic seizures alone

  • Progressive myoclonus epilepsies (PME)

  • Autosomal dominant epilepsy with auditory features (ADEAF)

  • Other familial temporal lobe epilepsies

  • Less specific age relationship

  • Familial focal epilepsy with variable foci (childhood to adult)

  • Reflex epilepsies


Overview of seizures and epilepsy

  • Distinctive constellations

  • Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE with HS)

  • Rasmussen syndrome

  • Gelastic seizures with hypothalamic hamartoma

  • Hemiconvulsion–hemiplegia–epilepsy

  • Epilepsies that do not fit into any of these diagnostic categories can be distinguished first on the basis of the presence or absence of a known structural or metabolic condition (presumed cause) and then on the basis of the primary mode of seizure onset (generalized vs. focal)

  • Epilepsies attributed to and organized by structural-metabolic causes

  • Malformations of cortical development (hemimegalencephaly, heterotopias, etc.)

  • Neurocutaneous syndromes (tuberous sclerosis complex, Sturge-Weber, etc.)

  • Tumor

  • Infection

  • Trauma

  • Angioma

  • Perinatal insults

  • Stroke

  • Etc.

  • Epilepsies of unknown cause

  • Conditions with epileptic seizures that are traditionally not diagnosed as a form of epilepsy per se

  • Benign neonatal seizures (BNS)

  • Febrile seizures (FS)


Not everything that looks like a seizure is a seizure

Not everything that looks like a seizure is a seizure

  • Migraine headache

  • Syncope

  • Psychogenic seizure

  • Behavioral outbursts

  • Breath holding spells

  • Tics

  • Sleep disorders


Diagnosing epilepsy

Diagnosing Epilepsy

  • Detailed history and physical examination

  • EEG, video EEG

  • Imaging ( CT, MRI, PET)


History

History

  • Precipitating factors

  • Aura

  • Area of body first involved

  • Progression of activity

  • Specific activity observed (head or eye deviation, type of movement or posturing)

  • Level of consciousness

  • Incontinence

  • Apnea or cyanosis

  • Duration of seizure

  • Postictal symptoms ( confusion, hemiplegia, aphasia)


Seizure triggers

Seizure Triggers

  • Missed dose of medication

  • Sleep deprivation

  • Illness

  • Stress, anxiety, overstimulation

  • Hormonal changes

  • Alcohol and drugs of abuse

  • Hyperventilation

  • Flashing lights

  • Temperature extremes

  • dehydration


Spectrum of severity

Spectrum of Severity


Psychosocial effects of epilepsy

Psychosocial effects of epilepsy

  • Stigma of epilepsy

  • Compromised quality of life

  • Lower self-esteem

  • “Vulnerable child”

  • High incidence of depression, anxiety, ADHD and learning problems

  • Adverse effects of medications

  • Parental stress


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