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Haemopoiesis Clinical application

Introduction. Life spanGranulocytesErythrocytesPlateletsLymphocytes. Introduction. Stem cellsSelf renewalPlasticityProgenitor cellsDevelopmentally-restricted cellsMature cellsMature cell production takes place from the more developmentally-restricted progenitors. Cell hierarchy (Haemopo

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Haemopoiesis Clinical application

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    1. Haemopoiesis Clinical application Dr. Tariq M. Roshan Department of Hematology PPSP

    2. Introduction Life span Granulocytes Erythrocytes Platelets Lymphocytes Every day 1013 myeloid cells must be produced. In steady state the number of cells which are required is equal to the body weight. All these cells are derived from the stem cells. Stem cells are relatively few in number, comprising 0.01% to 0.05% of the marrow cells.Every day 1013 myeloid cells must be produced. In steady state the number of cells which are required is equal to the body weight. All these cells are derived from the stem cells. Stem cells are relatively few in number, comprising 0.01% to 0.05% of the marrow cells.

    3. Introduction Stem cells Self renewal Plasticity Progenitor cells Developmentally-restricted cells Mature cells Mature cell production takes place from the more developmentally-restricted progenitors

    4. Cell hierarchy (Haemopoiesis schematic representation) Highly simplified diagram to demonstrate the stages of development of various cell types.Highly simplified diagram to demonstrate the stages of development of various cell types.

    6. Sites of Haemopoiesis Yolk sac Liver and spleen Bone marrow Gradual replacement of active (red) marrow by inactive (fatty) tissue Expansion can occur during increased need for cell production Embryonic haemopoietic stem cells-mesenchymal cells in yolk sac After 12 week fetal liver and spleen becomes the main site From week 20, bone marrow starts to become important and by the time of birth it is the main haemopoietic organEmbryonic haemopoietic stem cells-mesenchymal cells in yolk sac After 12 week fetal liver and spleen becomes the main site From week 20, bone marrow starts to become important and by the time of birth it is the main haemopoietic organ

    7. Stem cells Self-renewal Normally in G0 phase of cell cycle The capacity for self-reproduction is vastly in excess of that required to maintain cell production for normal lifetime As cells increase in number they differentiate as well Multipotentiality Capacity to generate cells of all the lymphohaemopoietic lineages

    9. Progenitor cells Encompasses from immediate progeny of stem cells to cells committed to one differentiation lineage Progenitor cells become progressively more restricted in their differentiation and proliferation capacity Late progenitor cells eventually restricted to one lineage

    10. Regulation of Haemopoiesis There should be a balance between cell production and cell death except at the times of requirement

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