Evolutionary Models. CS 498 SS Saurabh Sinha. Models of nucleotide substitution. The DNA that we study in bioinformatics is the end(??)-product of evolution Evolution is a very complicated process Very simplified models of this process can be studied within a probabilistic framework
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CS 498 SS
Source: Ewens and Grant, Chapter 14.
0.25 - 0.25(1-4)n
Transition probability proportional to the stationary
probability of the target nucleotide. Stationary distribution is
(a, g, c, t)
Looks like time has been reversed. That is, if we can find
a such that
The models we have seen today all have this property.