Celiac Disease in Children: The Calgary Clinic Data

1. Celiac Disease in Children:The Calgary Clinic Data Calgary Celiac Disease Conference 25 October 2008 J. Decker Butzner, MD, FRCPC Head , Division of Pediatric Gastroenterology Alberta Children�s Hospital, Professor, University of Calgary 1

2. Disclosures Member Professional Advisory Board � Canadian Celiac Association Member Professional Advisory Board � Canadian Celiac Association �Calgary Chapter Financial Disclosures - Nil 2

3. Objectives Provide an update on the genetics and pathophysiology of celiac disease Southern Alberta data on celiac disease in children Diagnosis Follow up Compare to Canadian Pediatric Celiac Survey from 2002 3

4. Definition Celiac disease is an autoimmune condition Occurs in genetically susceptible individuals DQ2 and/or DQ8 positive HLA haplotype is necessary but not sufficient A unique autoimmune disorder because: both the environmental trigger (gluten) and the autoantigen (tissue Transglutaminase) are known elimination of the environmental trigger leads to a complete resolution of the disease 4