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IMUNOGENETICS

IMUNOGENETICS. prof. Ing. Karel Hála, CSc. Universit ät Insbruck Rakousko.

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IMUNOGENETICS

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  1. IMUNOGENETICS prof. Ing. Karel Hála, CSc. Universität Insbruck Rakousko

  2. Immunogenetics- application of methods of immunology to the recognition of individual differences(e.g. blood groups, protein allotypes, transp. antigens)- application of genetic methods to the study of immunological phenomena(e.g. mechanisms determining antibody induction, disease resistance, autoimmunity) • Edward Jenner - 1796 (cowpox - protection against human smallpox) • Gregor J. Mendel - 1865 • Karl Landsteiner - 1900 (ABO blood group) • M.R. Irwin - 1947 (Streptopelia chinensis, S. risoria) • George Snell - 1948 (kongenní kmeny myší)

  3. Transplantation antigensAutograft, syngeneic graft, allograftFirst-set rejection, second-set-rejection

  4. The expression of MHC molecules differs between tissues

  5. HLA genes are highly polymorphic

  6. MHC class I Molecule MHC class II molecules

  7. Buněčné elementy v kostní dřeni, v krvi a v tkáních

  8. Přehledy vazebných motivů peptidů pro interakci s MHC gp1

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