Why Is Cancer Therapy Such a Difficult
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Why Is Cancer Therapy Such a Difficult and Often Intractable Effort?. Cancer Genome Landscapes. Science, Vol. 339, March 29, 2013, pp 1546 – 1548 Bert Vogelstein, Nickolas Papadopoulos, Victor Velculescu, Shibin Zhou, Luis Diaz, Kenneth W. Kinzler

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VogelsteinScience15Apr13 Updated: April 15, 2013

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Vogelsteinscience15apr13 updated april 15 2013

Why Is Cancer Therapy Such a Difficult and Often Intractable Effort?

Cancer Genome Landscapes.

Science, Vol. 339, March 29, 2013, pp 1546 – 1548

Bert Vogelstein, Nickolas Papadopoulos, Victor Velculescu, Shibin Zhou, Luis Diaz, Kenneth W. Kinzler

Howard Hughes Medical Institute at Johns Hopkins Kimmel Cancer Center, Baltimore

VogelsteinScience15Apr13.ppt

Updated: April 15, 2013


Vogelsteinscience15apr13 updated april 15 2013

Number of somatic mutations associated with cancers in patients


Vogelsteinscience15apr13 updated april 15 2013

From 5 or 10 to 130 to 700 mutations per tumor


Vogelsteinscience15apr13 updated april 15 2013

(Insertions & deletions)

(Single base substitutions)


Vogelsteinscience15apr13 updated april 15 2013

Signaling

Pathways

Affected

In Cancers


Vogelsteinscience15apr13 updated april 15 2013

Pathway Anomalies in Progression in Colo-Rectal Cancer


Vogelsteinscience15apr13 updated april 15 2013

The RAS Pathway as a representative signaling pathway affected by cancer mutations and approaches to therapy based on RAS pathway anomalies

RTK = receptor tyrosine kinase


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