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# Computer Generated Vasculature PowerPoint PPT Presentation

Computer Generated Vasculature. Laboratory for Product and Process Design Undergraduate: Dexter Teng Mentors: Brian Sweetman & Andreas Linninger Date: February 4th, 2010. Motivation.

Computer Generated Vasculature

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## Computer Generated Vasculature

Laboratory for Product and Process Design

Mentors:Brian Sweetman & Andreas Linninger

Date:February 4th, 2010

### Motivation

• MAIN GOAL: Reconstruct accurate model of brain vasculature using Constrained Constructive Optimization (CCO) algorithm.

### Significance

• Contribute to an overarching goal of constructing a model to better quantify brain physics interaction between:

• CSF (Ventricular system)

• Blood (Vascular system)

• And Brain Tissue…

• … in order to improve treatment and diagnosis of CNS diseases.

### Preliminary Goal (Goal 1)

• Understand how to reconstruct a vascular system with simple constraints using CCO algorithm

• 1. Literature search.

• 2. Understand CCO algorithm.

• Review vector algebra

• 3. Choose & develop data structure.

• Timeline: Week 1-5 (5)

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### 2. What is CCO algorithm?

• A set of rules based on physiological laws for pseudo-stochastic growth of a fractal system [in this case our system is the vasculature].

• Know: # of terminal points, bifurcation exponent (for radii shrinkage), perfusion pressure/flow, terminal pressure/flow, viscosity of blood and size of medium (circle, heart, brain etc)

• More work needs to be done.

• Review Smit’s work.

### 3.Data Structure

• Important - organization of nodes is the most important aspect of CCO. Versatility is required because of the nature of CCO.

• Requires that nodes are traversable, removeable and readjustable

• Possible Data Structures

• Arrays

• Binary Tree

• Programming needs to be done.

### Semester Goals

• Goal 2: Reconstruct a small 2-D vasculature in circle

• 1. Program CCO algorithm on MATLAB

• 1.1 Have algorithm compatible with data structure code.

• 2. Begin technical report.

• Weeks 6-8 (3)

• Goal 3: Reconstruct a small 3-D Vasculature in small sphere

• 1. Literature search on previous works done.

• 2. Work on program.

• 3. Revise technical report.

• Weeks 9-13 (5)

• Goal 4: Reconstruct a 3-D vasculature in a model brain. [Ventricular system/Brain Tissue]

• Revise technical report.

• 13-16 (4)