U.S. Food and Drug Administration. Notice: Archived Document The content in this document is provided on the FDA’s website for reference purposes only. It was current when produced, but is no longer maintained and may be outdated. . Importance of Macrolides in Human Medicine.
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Notice: Archived Document
The content in this document is provided on the FDA’s website for reference purposes only. It was current when produced, but is no longer maintained and may be outdated.
John H. Powers, MD
Lead Medical Officer
Antimicrobial Drug Development and Resistance Initiatives
Office of Drug Evaluation IV
Center for Drug Evaluation and Research
U.S. Food and Drug Administration
Structure of erythromycin
1) Antimicrobial used to treat enteric pathogens that cause food borne disease
2) Sole therapy or one of few alternatives to treat serious human disease or drug is essential component among many antimicrobials in treatment of human disease
3) Antimicrobials used to treat enteric pathogens in non-food-borne disease
4) No cross-resistance within drug class and absence of linked resistance with other drug classes
5) Difficulty in transmitting resistance elements within or across genera and species of organisms