Enteroviruses
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ENTEROVIRUSES. Family PICORNAVIR IDAE Enterovirus полиовирусы (возбудители полиомиелита) – 3 серотипа - вирусы Коксаки А – 24 серотипа - вирусы Коксаки В – 6 серотипов - вирусы ЕСНО – 34 серотипа - энтеровирусы серотипов 68 - 71 Rhinovirus. Строение вириона энтеровирусов.

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ENTEROVIRUSES

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Enteroviruses

ENTEROVIRUSES

Family PICORNAVIRIDAE

Enterovirus

( ) 3

- 24

- 6

- 34

- 68 - 71 Rhinovirus


Enteroviruses

22-30

60 , 12 ()

4 VP1, VP2, VP3, VP4

VP1, VP2, VP3

VP4


Enteroviruses

-

5` VPg


Enteroviruses

VP1

() ,

(), . 71


Enteroviruses

:

- ( 2,5-11,0);

- , , - ;

- ;

- , ; , ;

-


Enteroviruses

:

- -;

- ;

- ;

- ;

- ;

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Enteroviruses

.

- ( -)

( , ), , ( ), ,


Enteroviruses

2-7

, , .

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Enteroviruses

()

, .

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.


Enteroviruses

-

, ,

,


Enteroviruses

-

-

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Enteroviruses

()

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- 1-4 , , , .

3-6 (


Enteroviruses

1-3

3-5


Enteroviruses

( , , , )

30-40 15

( , )

3-7


Enteroviruses

1-2 -

3


Enteroviruses

, ,


Enteroviruses

, ,


The poliovirus life cycle

The Poliovirus Life Cycle


Enteroviruses

90%

( )

( )

( )


Enteroviruses

, , , ( )

, , , ( , )

- ( )


Enteroviruses

  • , IgG sIgA


Enteroviruses

  • 1,2,3

  • 1,2 3 , . / /


Enteroviruses

  • 3 - 4,5 6

  • 1- - 18

  • 2- - 20

  • 3- - 14


Enteroviruses

  • 120 , . .

  • -

    -


Enteroviruses

  • .Reoviridae, Rotavirus

  • .Caliciviridae, Calicivirus, (Norwolk)

  • .Astroviridae

  • .Picornaviridae, Enterovirus, ,

  • .Adenoviridae, Mastadenovirus

  • .Coronaviridae, Coronavirus


Enteroviruses

  • 60%

  • , 5

  • 137 , 592 .


Enteroviruses

  • , 6 18 (70-80% ), ,


Enteroviruses

  • . Reoviridae, Rotavirus, .

  • Rotavirus A, B, C, D, E, F, G, VP6

  • , () VP4 VP7

  • .

  • 4 P8G1, P8G3, P8G4, P4G2


Enteroviruses


Enteroviruses

  • 65-75

  • - ( ), -

  • , (rota )


Enteroviruses

  • ,

  • 11 3 (VP1, VP2, VP3)

  • 260 VP6

  • 780 , VP7, VP4

  • ( )


18 20

18-20

  • - -

  • - ( )


Enteroviruses

  • - -

  • ( VP7, VP4, NS28)

  • , ,


Enteroviruses

  • 15 1

  • 7

  • 2

  • 30


Enteroviruses

  • 95%


Enteroviruses

  • , .

  • -


Enteroviruses

  • 12-

  • ,


Enteroviruses

  • , , , , ()

  • ,

  • ,


Enteroviruses

  • 12 5 ( 1-2 )

  • : , , , , , , ,

  • , , ,

  • 3-7

  • 8-10 , 2


Enteroviruses

  • , IgG- sIg-

  • - -,

  • ,


Enteroviruses

  • 3- ,


Diagnosis

Speciemens

Throat swabs

Rectal swabs

Stool

Cerebrospinal fluid

serum

Methods

IF

Reverse transcription-polimerase chain reaction

Cell culture

Serological (passive agglutination, CFT)

DIAGNOSIS


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