血管生理功能評估研究室

1. 血管生理功能評估研究室  主持教師: 顏嘉宏 博士 (助理教授/生命科學系)  專長: 血管健康功能評估、氧化壓力功能評估、疾病動物模式 建立(高血壓、糖尿病或高同半胱氨酸血症)  目前研究主題: (1)由植物萃取物中篩選具有血管保健、血糖調節或是血壓調節之潛力成分 (2)尋找具有促進傷口癒合之潛力成分 (3)環境汙染物對哺乳類動物的心血管系統及氧化壓力之影響 糖尿病鼠 氧化壓力測量 血管張力功能測量  腦中風之大鼠(高血壓導致)  國際期刊發表(2008~2010): •  Yu HP, Hsu JC, Hwang TL, Yen CH, Lau YT. Resveratrol attenuates hepatic injury after trauma-hemorrhage via estrogen receptor-related pathway. Shock. 2008(Sep);30(3):324-8 • Yu HP, Hsu JC, Yen CH, Ma YH, Lau YT. Hyporeactivity of renal artery to angiotensin II in septic rats. Chin J Physiol. 2008(Oct); 51(5): 301-7. • Sheu JJ, Yuen CM, Sun CK, Chang LT, Yen CH, Chiang CH, Ko SF, Pei SN, Chua S, Bhasin A, Wu CJ, Yip HK. Six-month angiographic study of immediate autologous bone marrow mononuclear cell implantation on acute anterior wall myocardial infarction using a mini-pig model. Int Heart J. 2009(Mar);50(2):221-34. • Sheu JJ, Chua S, Sun CK, Chang LT, Yen CH, Wu CJ, Fu M, Yip HK. Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction. Int J Cardiol. 2009(Sep). • Sun CK, Yuen CM, Kao YH, Chang LT, Chua S, Sheu JJ, Yen CH, Ko SF, Yip HK. Propylthiouracil attenuates monocrotaline-induced pulmonary arterial hypertension in rats. Circ J. 2009(Sep);73(9):1722-30. • Hsieh CY, Miaw CL, Hsieh CC, Tseng HC, Yang YH, Yen CH* (Corresponding author). Effects of chronic 4-n-nonylphenol treatment on aortic vasoconstriction and vasorelaxation in rats. Arch Toxicol. 2009(Oct);83(10):941-6. • Yu HP, Hwang TL, Hwang TL, Yen CH, Lau YT. Resveratrol prevents endothelial dysfunction and aortic superoxide production after trauma hemorrhage through estrogen receptor-dependent hemeoxygenase-1 pathway. Crit Care Med. 2010;38(4):1147-54. • Yen CH, Ma YH, Yu HP, Lau YT. Reduction of superior mesenteric hemodynamic responsiveness to [Sar1, Thr8]-angiotensin II and bradykinin, but not sodium nitroprusside, in the presence of homocysteine infusion. Chin J Physiol. 2010 Feb. • Yen CH, Leu S, Lin YC, Kao YH, Chang LT, Chua S, Fu M, Wu CJ, Sun CK, Yip HK. Sildenafil Limits Monocrotaline-Induced Pulmonary Hypertension in Rats through Suppression of Pulmonary Vascular Remodeling. J Cardiovasc Pharmacol. 2010 Mar  產學合作計畫案: • 改良體外血管硬度測量儀 • 評估並改良寵物用傷口癒合促進劑  聯絡方式: 辦公室電話： 08-7703202 ext.6368