The TLR5 1174C>T Polymorphism in Melioidosis Infection. Chief of Medicine Conference 10/2/12 Presented by Amy Dickey, MD R2, Internal Medicine Principal Investigator: Eoin West, MD MPH. Outline. Background: What is m elioidosis ? What are Toll Like Receptors?
Chief of Medicine Conference 10/2/12
Presented by Amy Dickey, MD
R2, Internal Medicine
Principal Investigator: Eoin West, MD MPH
Figure 1. The global distribution of Melioidosis. NEJM Sept 13, 2012.
Figure 2: Toll like receptor signaling pathways
Table 1: TLR51174C>T genotype and in-hospital mortality
Figure 4. IL-8 expression
Figure 3. GCSF expression
The TLR51174C>T polymorphism increases NF-kB expression in response to LPS.
Figure 6. NF-kB activation
Surprisingly, the TLR5 polymorphism increases NF-kB expression but decreases IL8 expression in response to LPS.
Figure 7. NF-kB activation
Figure 8. IL-8 expression
Figure 9: IL-8 expression assay
The West Lab
Members of the Wurfel and Skerrett labs.