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Announcements

Announcements. Begin literature search! Locate a minimum of 1 review article & 2 peer reviewed research articles. Type out a reference list & have a copy of the papers turned in by Feb 4 ! Worth a 10 pt quiz grade. Exam 1: Mon, Jan 28 Chapter 1. Antigen Presentation to T- cells. continued.

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Announcements

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  1. Announcements • Begin literature search! • Locate a minimum of 1 review article & 2 peer reviewed research articles. • Type out a reference list & have a copy of the papers turned in by Feb 4! • Worth a 10 pt quiz grade. • Exam 1: Mon, Jan 28 • Chapter 1

  2. Antigen Presentation to T- cells continued

  3. The Endogenous Pathway: • MHC class I • Endogenous Ag: • derived from pathogens that multiply intracellularly.

  4. Exogenous Pathway • MHC class II • Exogenous antigen: • derived from pathogens that multiply outside of host cells or inside the phagolysosome.

  5. How are T cells Activated?

  6. T cells engage cells carrying the MHC with antigen. Immunology (kuby)

  7. For successful T cell engagement of the APC:

  8. Toxic granules released Virally infected CHO cells. Fig. 1.26, p. 24

  9. What does the interaction of T cells with the APC accomplish?

  10. Why do T cells need to undergo positive & negative Selection to achieve tolerance?

  11. The Humoral Immune Response Activation of B cells

  12. 1. T Independent Antigens Fig. 16-14, nester Microbiology

  13. 2. T dependent antigens: Fig. 1.21, Janeway (6th ed)

  14. Clonal selection & clonal expansion Generally require Th2 cell assistance

  15. What are the activities of Antibody?

  16. perforin

  17. Antibody Function: Fig. 1.29, 2nd ed Immune Complex formation

  18. http://www.bmb.psu.edu/courses/bisci004a/immune/activate.jpg

  19. Overview of the two arms of adaptive immunity: Humoral Immunity & Cell Mediated Immunity.

  20. Fig. 1.7, Immunology (kuby) 4th ed B cell internalizes Ag & now is an APC

  21. Th2 cells Th1 cells • Fig. 1.13, p. 13, Immunology (kuby) 4th ed

  22. Adaptive Immunity Demonstrates Primary & Secondary Responses:

  23. Adaptive Immunity- Primary & Secondary Responses: p. 28, Parham

  24. Mouse A receives skin grafts T cells demonstrate primary & secondary responses

  25. Improper immune responses may lead to allergies or autoimmune disease.

  26. Coxsackie viruses

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