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老人の薬物 PowerPoint PPT Presentation


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老人の薬物. 16 班: 奥薗                       重田                      松田                     突田                      高野                        指導:村上先生. Case history. 79 才女性 消化管の内視鏡検査予定 内視鏡検査時、精神安定のためジアゼパム  2mg投与 五分後症状改善せず さらに5mgジアゼパム投与 検査後呼吸困難とチアノーゼ様相表れる その後ICUへ. ベンゾジアゼピン系の作用機序.

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老人の薬物

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16


Case history

  • 79


GABAGABAA

Cl channel Cl


GABAA,

GABAA



(

  • case history)


COPD


(99%


  • (

  • (

    biotransformation


biotransformation

Biotransformation()

prodrug


cytocrome P450)


ClH

M = Q ( Ci Co )

M :

Q :

Ci :

Co:

MCiClH

ClHQ ( Ci Co ) / Ci


  • (


  • 180 /

  • (Ex.Penicillin)


C l p=UP/C p

C l p :

:

P :

C p :

(GFR)(clearance ratio)11



pH

pH



Vd

  • Lean body mass

  • VdVdV

    distribution


1520


AAG(1 Acid Glycoprotein)

AAG

AAGAAGVd


AAGVdVdAAGVd




(AUC)





(

Cl({140 (}IBW

Cl( 72C(ms/dl)

Cl(0.85

Cl :(ml/

IBW :

C :/







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