Cell migration in the cerebral cortex How does it work What happens when it goes wrong Story of interplay between b

Inside-out programme of neurogenesis. Somal translocation. Glial-guided locomotion. ?Reeler" mutant mice Mice are ataxic, fall over a lot Lack cerebellum Layers in cerebral cortex are inverted . Inverted cortical layers in reeler mutants. ?Reeler" mutation mapped to gene, named Reelin. Encodes large secreted protein Specifically expressed by Cajal-Retzius cells in marginal zone of developing cortex Mutations in the human Reelin gene result in Lissencephaly with Cerebellar Hypoplasia.

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