Problems. Maisam : S piral waves did not change when when parameters changed due to keeping the ratio between my group\'s parameters 1:1. C hang ing only one parameter at a time caused changes with the spiral waves .
PowerPoint Slideshow about ' Problems' - yul
An Image/Link below is provided (as is) to download presentation
Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.
Maisam: Spiral wavesdid not change whenwhen parameters changed due to keeping the ratio between my group\'s parameters 1:1.Changingonly one parameter at a time caused changes with the spiral waves.
Girish: I started my run by setting Gna to 50 percent. There was no wave. Sodium ions are the first players in an action potential. So if their concentration is below a certain level, then the current cannot reach the threshold to excite the cell.
Naralys: The waves created often times were vague and difficult to differentiate from each other.
Ruth: It was not clear what cells we are observing (epi/endo/M cells) which each has different value for Gks. Another issue was how long to wait to observe a patterned, but that was solved by trying different time intervals.
Maisam: After reducing the inward Calcium current by five percent each time and keeping the Potassium conductance the same, I created an instability in the system, causing several spiral waves to form. The more I reduced the inward Calcium current, the more unstable the waves became. But after a certain point of reducing the inward Calcium current, the extent to which the system destabilized became less. In other words, there were less spiral waves. I would like to repeat these simulations with the same parameters next time.
Girish: After noticing that at 50% the model died. I then tried to find the minimal percent value that can be had to actually produce a spiral wave. After 2 runs, I found that number to be 65.29 for Gna. Whats even more interesting is that at this specific value, their are two spiral waves initiated but they collide and destroy each other! What could this mean? It means there could be a certain value or concentration of ions at which the spiral wave can actually destroy themselves. I also found the upper bound value of Gna to be 394%.