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Neural Transplantation

This case study examines the use of neural transplantation in the treatment of a patient with a humeral fracture and evulsion of the musculocutaneous nerve in the brachial plexus. It explores the transplantation of the phrenic nerve and the role of Schwann's cells in promoting axon regeneration and functional recovery. The study references relevant anatomical and medical literature.

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Neural Transplantation

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  1. Neural Transplantation A virtual case study Wang Siheng 10301010032 Prof. Gu YD, a doctor in Huashan Hosp. Xu Heyang 10301010042 Gu’s student

  2. Chief Complaint • Mr. Zhang Ning • Age: 22 • Car accident • Humeral fracture • Evulsio of musculocutanous nerve

  3. Brachial Plexus • Source • C5-C8, T1 • Five main branches • musculocutanous nerve （肌皮神经） • median nerve • ulnar nerve • radial nerve • axillary nerve

  4. Musculocutanous Nerve • Motor • Coracobrachialis（喙肱肌） • Brachialis（肱肌） • Biceps brachii（肱二头肌） • Sensory • Skin on the lateral part of arm

  5. Phrenic Nerve as a Transplant • Fibers • Phrenic nerve: 2700 • Accessory nerve: 2200 • Intercostal nerve: 600-700 • Success rate • Phrenic nerve: 84% • Accessory nerve: 72% • Intercostal nerve: 68%

  6. Schwann’s Cell In model animals Survival Migration Axon-glia association Observed within 3d – 9w after transplantation Growing axons induced by Schwann’s cell

  7. Key Words • Evulsio • Musculocutaneous nerve • Phrenic nerve • Brachial plexus • Schwann’s cell • Ward-round

  8. References • 顾玉东. 臂丛神经根性撕脱伤治疗进展[J]. 中华显微外科杂志,2002,(01):5-7 • 柏树令, 系统解剖学.第 2 版. 2011, 北京: 人民卫生出版社. • GU, Y.D., et al., Phrenic-Nerve Transfer for Brachial-Plexus Motor Neurotization. Microsurgery, 1989. 10(4): p. 287-289. • Pearse, D.D., et al., Transplantation of Schwann cells and/or olfactory ensheathing glia into the contused spinal cord: Survival, migration, axon association, and functional recovery. GLIA, 2007. 55(9): p. 976-1000. • Oudega, M. and X.M. Xu, Schwann cell transplantation for repair of the adult spinal cord. JOURNAL OF NEUROTRAUMA, 2006. 23(3-4): p. 453-467. • Schuenke, M., E. Schulte and U. Schumacher, THIEME Atlas of Anatomy. 2007, New York: Thieme Medical Publishers, Inc. • Goldman, L. and A.I. Schafer, Goldman’s Cecil medicine. 24th ed. 2012, Philadelphia: Elsevier Inc.

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