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Student Research Interest HER2 Receptor Signaling in Breast Cancer Cells

Student Research Interest HER2 Receptor Signaling in Breast Cancer Cells. Marc Y. Fink Biomedical Sciences LIU-Post. HER2 and Breast Cancer. Amplification or chromosomal region 17q12 RTK of the EGFR-family

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Student Research Interest HER2 Receptor Signaling in Breast Cancer Cells

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  1. Student Research InterestHER2 Receptor Signaling in Breast Cancer Cells Marc Y. Fink Biomedical Sciences LIU-Post

  2. HER2 and Breast Cancer • Amplification or chromosomal region 17q12 • RTK of the EGFR-family • HER2 is overexpressed and induces a state in which proliferation and survival are increased • Several drugs are approved for molecularly tailored treatment (trastuzumab and lapatinib) • They often induce resistance after 1-2 years of treatment

  3. HER2 Signaling HER2 FGFR IGF1R P P • Shc • Grb2 SOS P P P P PI3K What are the intracellular targets that may be useful for targeting HER2-breast cancers? How does the network reorganize after HER2 inhibition? Ras * AKT Raf TSC1 TSC2 MEK 1/2 Rheb mTORC 1 ERK 1/2 * * p70S6k RSK S6

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