pathophysiology of adrenocortical hormone
Download
Skip this Video
Download Presentation
PATHOPHYSIOLOGY OF ADRENOCORTICAL HORMONE

Loading in 2 Seconds...

play fullscreen
1 / 15

PATHOPHYSIOLOGY OF ADRENOCORTICAL HORMONE - PowerPoint PPT Presentation


  • 121 Views
  • Uploaded on

PATHOPHYSIOLOGY OF ADRENOCORTICAL HORMONE. Dr. Amel Eassawi. Objectives. At the end of this lecture the student should be able to: Describe Pathophysiology of hypo and hyperpadrenalism .

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about ' PATHOPHYSIOLOGY OF ADRENOCORTICAL HORMONE' - yasuo


An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
objectives
Objectives

At the end of this lecture the student should be able to:

  • Describe Pathophysiology of hypo and hyperpadrenalism.
  • Correlate the features of hypo and hyper adrenalism with the physiological action and control mechanism of adrenocortical hormones.
  • Describe the different stress mechanisms and the body’s response to these stressors.
pathophysiology1
Pathophysiology
  • Primary hyperaldosteronism, or Conn’s syndrome)-Adrenal tumor.
  • Secondary hyperaldosteronism- inappropriately high activity of the renin-angiotensin-aldosterone system.
  • Cortisol hypersecretion - (Cushing’s syndrome).
  • Adrenal androgen hypersecretion – adrenogenital syndrome.
hyperaldosteronism
HYPERALDOSTERONISM
  • Primary hyperaldosteronism, or Conn’s syndrome
    • Cause:
      • Adrenal tumor of aldosterone –secreting cells
  • Secondary hyperaldosteronism
    • Cause:
      • inappropriately high activity of the renin-angiotensin-aldosterone system.

Symptoms:

  • excessive Na+ retention (hypernatremia) and
  • K +depletion (hypokalemia).
  • high blood pressure (hypertension)
cushing s syndrome
CUSHING’S SYNDROME
  • Cause
    • Overstimulation of the adrenal cortex by excessive amounts of CRH and/or ACTH,
    • Adrenal tumors that uncontrollably secrete cortisol independent of ACTH,
    • ACTH-secreting tumors located in places other than the pituitary, most commonly in the lung
cushing s syndrome1
CUSHING’S SYNDROME
  • Features
    • High blood glucose
    • Glucosuria – Adrenal diabetes
    • Protein shortage
    • Buffalo hump
    • Moon face
    • Thin extremities, weakness & fatigue
    • Reddish – purple linear stria
adrenal androgen hypersecretion
ADRENAL ANDROGEN HYPERSECRETION
  • Adrenogenital syndrome
  • In adult females
    • Male pattern of body hair
    • Deep voice
    • Muscular arms & leg
    • Decrease breast size, menstrual suppression
adrenal androgen hypersecretion1
ADRENAL ANDROGEN HYPERSECRETION
  • Adrenogenital syndrome
  • In newborn females
    • Male type of external genitalia
    • female pseudohermaphroditism
  • In pubertal males
    • prematurely develop male secondary sexual characteristics
    • precocious pseudopuberty
  • In adult males
    • No apparent effect
adrenocortical insufficiency
ADRENOCORTICAL INSUFFICIENCY
  • Primary adrenocortical insufficiency, also known as Addison’s disease
    • Autoimmune destruction of cortex
  • Features are related to Aldosterone deficiency
    • K+retention (hyperkalemia),
    • Na+depletion (hyponatremia),
    • disturbed cardiac rhythm.
    • Hypotension
  • Features are related to cortisol deficiency
    • poor response to stress,
    • hypoglycemia (low blood glucose)
    • hyperpigmentation (darkening of the skin)
references
References
  • Human physiology, Lauralee Sherwood, seventh edition.
  • Text book physiology by Guyton &Hall,11th edition.
  • Text book of physiology by Linda .S .Costanzo third edition
ad