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第二十章 分析性 研 究 第一节 队列研究 PowerPoint PPT Presentation


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第二十章 分析性 研 究 第一节 队列研究. 邹焰. 分析性研究 (analytical study) ,亦称分析流行病学,该方法一般是选择一个特定的人群,对由描述性研究提出的病因或流行因素的假设进行分析检验。常用的分析性研究有队列研究和病例对照研究。. 一、概念. ( 一 ) 定义 队列研究 (cohort study) 是选定暴露于某因素及末暴露于某因素的两组或不同暴露水平的人群,追踪观察一定的时间,比较各组人群疾病结局发生率的差异,从而判断所研究因素与疾病之间有无因果关联及关联强弱的一种观察性研究方法。.

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第二十章 分析性 研 究 第一节 队列研究

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(analytical study)


()

(cohort study)


Cohort () ()


(exposure)


()


(incidence study) (prospective study) (longitudinal study) (follow-upstudy)


:(fixed cohort)(dynamic population)


()

1

2

3


1

2)

3 "

4


1prospective cohort study) (concurrent cohort study)

;


2.(historical cohort study)


3(ambispective cohort study)



()

1

2 (>5)

3

4 ()

5


()



()

-


()

(outcome) (outcome variable


()

1

(1)

(2)

(3)


2

(1):

(2):

A. B. C.

(3)


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1

(1)p0

(2)(RR)

(3)(a)

(4) (power)1


3

p0RR

10%


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:

1

2

3


()

1

2


()

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2

(1):

a (cumulative incidence) ()

b(incidence density)


2


RRRR (confidence intervalCI)95%Miettinen:

RR95%CIRR(1 1.96/ )

RRRR1


RRARRR

AR


()

RRARRRAR-


DollHill-



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3

4


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2

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