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Exp

NLS. NLS. Imp. RXR. Imp. Imp. ErbB2. NoBP. Stat1a. UBS. CypB. rRNA genes. X. PLC g. ?. DNAPK. X. P. Exp. ErbB2. NES. CypB. RNA pol II. CCN2,3. PTHrP. SwGF. IGFBP2,3,5. IFN g. PRL. FGF2 LMW. NLS. FGF1. EGF. NLS. ?. Plasma membrane. ?. Tfr. ?. NLS. NLS.

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Exp

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  1. NLS NLS Imp RXR Imp Imp ErbB2 NoBP Stat1a UBS CypB rRNA genes X PLCg ? DNAPK X P Exp ErbB2 NES CypB RNA pol II CCN2,3 PTHrP SwGF IGFBP2,3,5 IFNg PRL FGF2 LMW NLS FGF1 EGF NLS ? Plasma membrane ? Tfr ? NLS NLS ErbB2 IFNgR1 TfrR NLS PRLR HSPG ? FGFR1 EGFR ErbB4 R2 R4 Imp ? Cytoplasm ? ErbB2 endocytosis Imp/Exp ErbB4 cleavage Exp ? Imp FGF2 HMW Early endosome Imp CypB FGF3 Late endosome Imp Stat1a mRNA splicing ? Imp Lysosome Splic Exp ? Imp Exp degradation + ? Exp Imp ? RNA Nucleolus Nucleus Exp NES (Ub)n + ? + RSK - DNA Repair ? + + + proteasome CBP RXR RXR Stat5 FT ? FT FT Stat1a Exp DNA RARE AT-Rich HAR RXRE promoter Basal transcription machinerie Specific target genes promoter Specific target genes + - + + Cell cycle Cell cycle, Lactation Apoptosis ?

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