1 / 24

Clinical Core Ron Petersen Paul Aisen Mike Donohue

Clinical Core Ron Petersen Paul Aisen Mike Donohue. ICAD July 10, 2010. ISAB requests. Impact of medications on decline AChEI Antihypertensives NSAIDs [PPAR gamma agonists (too few)]. AChEI v. no AChEI. MCI ADAS CDR-SB Hipp volume. BP meds v. no BP meds. MCI ADAS Hipp vol NL

xiu
Download Presentation

Clinical Core Ron Petersen Paul Aisen Mike Donohue

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Clinical Core Ron Petersen Paul Aisen Mike Donohue ICAD July 10, 2010

  2. ISAB requests • Impact of medications on decline • AChEI • Antihypertensives • NSAIDs • [PPAR gamma agonists (too few)]

  3. AChEI v. no AChEI • MCI • ADAS • CDR-SB • Hipp volume

  4. BP meds v. no BP meds • MCI • ADAS • Hipp vol • NL • Hipp vol

  5. NSAIDs v. no NSAIDs • MCI • ADAS • Hipp vol • NL • Hipp vol

  6. Predictors of conversion from NL

  7. Summary: key points • AChEI therapy is a powerful marker of increased decline in MCI • Anti-hypertensives and NSAIDs do not have much effect on progression in any group • The predictors of conversion to MCI from NL are APOE and ADAScog13

  8. Preview of Sunday symposium • Predictors of conversion from MCI to AD in multiple studies • Pieter Jelle Visser

  9. Univariate progression plots: CSF

  10. Univariate progression plots: FS hippocampal volume

  11. Univariate progression plots: ADAS13

  12. Univariate progression plots: MMSE

  13. Univariate progression plots: age

More Related