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Pulmonary Vascular Disease

Pulmonary Vascular Disease. Pulmonary Circulatuion. Dual supply Pulmonary arteries Bronchial arteries Low pressure system Pulmonary artery receives entire cardiac output (a filter). Low pressure system…. Thin walled vessels Low incidence of atherosclerosis At normal pressures.

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Pulmonary Vascular Disease

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  1. Pulmonary Vascular Disease

  2. Pulmonary Circulatuion • Dual supply • Pulmonary arteries • Bronchial arteries • Low pressure system • Pulmonary artery receives entire cardiac output (a filter)

  3. Low pressure system…. • Thin walled vessels • Low incidence of atherosclerosis At normal pressures

  4. Pulmonary Oedema • Accumulation of fluid in the lung • Interstitium • Alveolar spaces • Causes a restrictive pattern of disease

  5. Pulmonary Oedema (causes) • Haemodynamic ( hydrostatic pressure) • Due to cellular injury • Alveolar lining cells • Alveolar endothelium Localised – pneumonia Generalised – adult respiratory distress syndrome (ARDS)

  6. Increased pulmonary venous pressure • Left ventricular failure • Mitral stenosis • Mitral incompetence Pressure increase forces fluid into interstitial space. Initially compensated by lymphatic drainage

  7. Development of pulmonary oedema • Fluid builds up first in interstitial space “stiff lung” • Eventually gets into alveolar space

  8. Pulmonary Embolus • Common • Often subclinical • An important cause of sudden death and pulmonary hypertension 95% + of emboli are thromboemboli

  9. Embolus • A detached intravascular mass carried by the blood to a site in the body distant from its point of origin • Most emboli are thrombi – others include gas, fat, foreign bodies and tumour clumps

  10. Source of most pulmonary emboli….. • Deep venous thrombosis (DVT) of lower limbs

  11. Risk factors for PE are those for DVT…. • Factors in vessel wall (eg endothelial hypoxia) • Abnormal blood flow (venous stasis) • Hypercoaguable blood (cancer patients, post-MI etc) - Virchow’s triad

  12. Effects of PE • Sudden death • Severe chest pain/dyspnoea/haemoptysis • Pulmonary infarction • Pulmonary hypertension

  13. Effects of PE depend on… • Size of embolus • Cardiac function • Respiratory function

  14. Large emboli Death Infarction Severe symptoms Small emboli Clinically silent Recurrent pulmonary hypertension Effect of embolus size…

  15. Pulmonary Infarct (ischaemic necrosis) • Embolus necessary but not sufficient • Bronchial artery supply compromised (eg in cardiac failure)

  16. Pummonary Embolus

  17. Pulmonary infarct – tumour embolus

  18. Pulmonary Hypertension • Primary (rare, young women) • Secondary

  19. Pulmonary Hypertension (mechanisms) • Hypoxia (vascular constriction) • Increased flow through pulmonary circulation (congenital heart disease) • Blockage (PE) or loss (emphysema) of pulmonary vascular bed • Back pressure from left sided heart failure

  20. Morphology of pulmonary hypertension • Medial hypertrophy of arteries • Intimal thickening (fibrosis) • Atheroma • Right ventricular hypertrophy • Extreme cases (congenital heart disease, primary pulmonary hypertension) – plexogenic change/necrosis

  21. Pulmonary artery – intimal fibrosis

  22. Plexiform lesion – primary pulmonary hypertension

  23. “Cor Pulmonale” • Pulmonary hypertension complicating lung disease • Right ventricular hypertrophy • Right ventricular dilatation • Right heart failure (swollen legs, congested liver etc)

  24. Right ventricular hypertrophy and dilatation

  25. Pulmonary vasculitis • Arteritis with ischaemia and focal necrosis – Wegeners granulomatosis, polyarteritis nodosa • Anti basement membrane antibodies (Goodpasture’s disease)

  26. Wegeners granulomatosis

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