DNA Replication. ORC anneals to origin ORC recruits MCM MCM recruits Cdc45p Cdc45p recruits pol a /primase complex RFC displaces pol a and recruits PCNA PCNA recruits pol d DNA ligase stitches DNA fragments together. Regulation of replication. Once and only once Licensing DNA damage
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Phosphorylates to block binding
Binds to block transcriptional activity
Phosphorylates to stabilize & activate
Dephosphorylates to destabilize & inactivate