Heterozygous for all alleles in MHC II
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Heterozygous for all alleles in MHC II. DRA-m or p DRB1-m DRA-m or p DRB1-p DRA-m or p DRB3,4, or 5 m DRA-m or p DRB3,4, or 5 p DQA-m DQB-m DQA-p DQB-p DQA-m DQB-p DQA-p DQB-m DPA-m DPB-m DPA-p DPB-p DPA-m DPB-p DPA-p DPB-m.

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Heterozygous for all alleles in MHC II

DRA-m or p DRB1-m

DRA-m or p DRB1-p

DRA-m or p DRB3,4, or 5 m

DRA-m or p DRB3,4, or 5 p

DQA-m DQB-m

DQA-p DQB-p

DQA-m DQB-p

DQA-p DQB-m

DPA-m DPB-m

DPA-p DPB-p

DPA-m DPB-p

DPA-p DPB-m

Makes 12 (and some 16)

“HLA heterozygous individuals can express up to six class I and eight class II” - quote in Ch 3 conflicts with Figure A3.9 and my calculations


T cell lineage (Chapter 5)

Rearrangement

order

Outcome

  and  are rearranged ---> cell

  and  are rearranged ---> cell

  and  are rearranged ---> cell

  and  are rearranged ---> cell

  and  are rearranged ---> cell

  rearranged ( rearranged&excised) ---> cell

  and  are rearranged ---> cell

  and  are rearranged ---> cell

  and  are rearranged ---> cell

  and  are rearranged ---> cell

  rearranged ( rearranged&excised) ---> cell


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