Nanovaccine platform technology a new paradigm
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Nanovaccine Platform Technology: A New Paradigm. Balaji Narasimhan Department of Chemical and Biological Engineering Presented by: Sarah A. Rajala, Dean, College of Engineering. Why the Urgency?. Re-emergence of known diseases and rapid emergence of new diseases

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Nanovaccine Platform Technology: A New Paradigm

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Nanovaccine platform technology a new paradigm

Nanovaccine Platform Technology: A New Paradigm

Balaji Narasimhan

Department of Chemical and Biological Engineering

Presented by: Sarah A. Rajala, Dean, College of Engineering


Why the urgency

Why the Urgency?

  • Re-emergence of known diseases and rapid emergence of new diseases

  • Need to improve existing vaccines (e.g., 2012-13 influenza vaccine)

  • Antibiotic resistance

  • Unsustainable healthcare system

    • Therapeutics cost 20-1,000 times more than prevention technologies per healthcare $$ spent

FUTURE?

PRESENT


Nanovaccine platform technology a new paradigm

Vision: Nanovaccines will revolutionize our ability to prevent and treat disease

  • Bridge groundbreaking science with novel nanoscale platform technologies

    • Science-driven, first principles paradigm for vaccine design

  • Novel nanomedicine-driven platform technology for tomorrow’s vaccines

    • Inherently interdisciplinary

  • Systemsapproach encompassing bench-to-bedside considerations from the earliest stages of conceptualization


Competitive edge and differentiators

Competitive Edge and Differentiators

  • Systems approach to vaccine design

    • Design, delivery, and deployment

  • Technology niche

    • Needle-free

    • Single dose

    • No refrigeration

    • Combination therapies

  • Bench-to-bedside

  • Partnerships with universities, government laboratories, and industry

Images: Courtesy Johns Hopkins, Ideo, Ohio State, Mystic Pharmaceuticals, and Atlantis Online


Room temperature nanovaccines

Room Temperature Nanovaccines

  • Today’s vaccines need to be refrigerated

  • Refrigeration is a major component of the cost and a significant logistical roadblock

  • Innovation: exploit advances in materials science and nanotechnology to design a thermally stable subunit nanovaccine

  • Nanovaccine can be stored at room temperature or higher for up to one year and still maintain efficacy

Petersen et al, Mol Pharmaceutics (2012)


Tomorrow s nanovaccines

Tomorrow’s Nanovaccines?

Video courtesy of Mystic Pharmaceuticals


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