Nanovaccine platform technology a new paradigm
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Nanovaccine Platform Technology: A New Paradigm. Balaji Narasimhan Department of Chemical and Biological Engineering Presented by: Sarah A. Rajala, Dean, College of Engineering. Why the Urgency?. Re-emergence of known diseases and rapid emergence of new diseases

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Nanovaccine Platform Technology: A New Paradigm

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Nanovaccine Platform Technology: A New Paradigm

Balaji Narasimhan

Department of Chemical and Biological Engineering

Presented by: Sarah A. Rajala, Dean, College of Engineering


Why the Urgency?

  • Re-emergence of known diseases and rapid emergence of new diseases

  • Need to improve existing vaccines (e.g., 2012-13 influenza vaccine)

  • Antibiotic resistance

  • Unsustainable healthcare system

    • Therapeutics cost 20-1,000 times more than prevention technologies per healthcare $$ spent

FUTURE?

PRESENT


Vision: Nanovaccines will revolutionize our ability to prevent and treat disease

  • Bridge groundbreaking science with novel nanoscale platform technologies

    • Science-driven, first principles paradigm for vaccine design

  • Novel nanomedicine-driven platform technology for tomorrow’s vaccines

    • Inherently interdisciplinary

  • Systemsapproach encompassing bench-to-bedside considerations from the earliest stages of conceptualization


Competitive Edge and Differentiators

  • Systems approach to vaccine design

    • Design, delivery, and deployment

  • Technology niche

    • Needle-free

    • Single dose

    • No refrigeration

    • Combination therapies

  • Bench-to-bedside

  • Partnerships with universities, government laboratories, and industry

Images: Courtesy Johns Hopkins, Ideo, Ohio State, Mystic Pharmaceuticals, and Atlantis Online


Room Temperature Nanovaccines

  • Today’s vaccines need to be refrigerated

  • Refrigeration is a major component of the cost and a significant logistical roadblock

  • Innovation: exploit advances in materials science and nanotechnology to design a thermally stable subunit nanovaccine

  • Nanovaccine can be stored at room temperature or higher for up to one year and still maintain efficacy

Petersen et al, Mol Pharmaceutics (2012)


Tomorrow’s Nanovaccines?

Video courtesy of Mystic Pharmaceuticals


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