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Nanovaccine Platform Technology: A New Paradigm. Balaji Narasimhan Department of Chemical and Biological Engineering Presented by: Sarah A. Rajala, Dean, College of Engineering. Why the Urgency?. Re-emergence of known diseases and rapid emergence of new diseases

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nanovaccine platform technology a new paradigm

Nanovaccine Platform Technology: A New Paradigm

Balaji Narasimhan

Department of Chemical and Biological Engineering

Presented by: Sarah A. Rajala, Dean, College of Engineering

why the urgency
Why the Urgency?
  • Re-emergence of known diseases and rapid emergence of new diseases
  • Need to improve existing vaccines (e.g., 2012-13 influenza vaccine)
  • Antibiotic resistance
  • Unsustainable healthcare system
    • Therapeutics cost 20-1,000 times more than prevention technologies per healthcare $$ spent

FUTURE?

PRESENT

slide3

Vision: Nanovaccines will revolutionize our ability to prevent and treat disease

  • Bridge groundbreaking science with novel nanoscale platform technologies
    • Science-driven, first principles paradigm for vaccine design
  • Novel nanomedicine-driven platform technology for tomorrow’s vaccines
    • Inherently interdisciplinary
  • Systemsapproach encompassing bench-to-bedside considerations from the earliest stages of conceptualization
competitive edge and differentiators
Competitive Edge and Differentiators
  • Systems approach to vaccine design
    • Design, delivery, and deployment
  • Technology niche
    • Needle-free
    • Single dose
    • No refrigeration
    • Combination therapies
  • Bench-to-bedside
  • Partnerships with universities, government laboratories, and industry

Images: Courtesy Johns Hopkins, Ideo, Ohio State, Mystic Pharmaceuticals, and Atlantis Online

room temperature nanovaccines
Room Temperature Nanovaccines
  • Today’s vaccines need to be refrigerated
  • Refrigeration is a major component of the cost and a significant logistical roadblock
  • Innovation: exploit advances in materials science and nanotechnology to design a thermally stable subunit nanovaccine
  • Nanovaccine can be stored at room temperature or higher for up to one year and still maintain efficacy

Petersen et al, Mol Pharmaceutics (2012)

tomorrow s nanovaccines
Tomorrow’s Nanovaccines?

Video courtesy of Mystic Pharmaceuticals

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