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Mouse and zebrafish Pou5f1 share targets: Comparison with mouse Oct4 target sets

Is this specific for zebrafish? Or can we learn how to drive stem cells into specific cell types in mammals?. Overexpression of mouse Pou5f1 rescues zebrafish embryos mutant for Pou5f1 Evolutionary conservation of function.

winifred-cohen
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Mouse and zebrafish Pou5f1 share targets: Comparison with mouse Oct4 target sets

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  1. Is this specific for zebrafish?Or can we learn how to drive stem cells into specific cell types in mammals?

  2. Overexpression of mouse Pou5f1 rescues zebrafish embryos mutant for Pou5f1Evolutionary conservation of function

  3. Overexpression of mouse Pou5f1 rescues zebrafish embryos mutant for Pou5f1Evolutionary conservation of function • Mouse and zebrafish Pou5f1 share targets: • Comparison with mouse Oct4 target sets • (genes with homology info only): • Sharov et al, BMC Genomics 2008 • (Matoba et al., 2006 and Loh et al., 2006) 453 49 406 zebrafish mouse

  4. Relevance?

  5. Insight into controlled differentiation of stem cells to replace lost tissues:Regenerative medicine Use knowledge of combination of tissue specific repressors of differentiation to generate defined cell types

  6. Acknowledgements • & Rebecca Mössner, Kay Kotkamp, Bozena Polock, Björn Wendik, Esther Kur, Bernadette Lippok, Sungmin Song, Heinz-Georg-Belting, Martina Lachnit • Collaborations: Thorsten Kurz (ZBSA Genomics Core) Jens Timmer (FRIAS) Florian Geier Daria Onichtchouk Onichtchouk et al., Molecular Systems Biology, 6:354 Mar 9 - 2010 driever@biologie.uni-freiburg.de

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