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Miap

NGF-P75. Miap. Casp6. Casp3. N. Modeling Apoptosis. f(NGF). NGF. NGF. p75. NGF-P75. Miap. Casp6. Casp3. N. LAW OF MASS ACTION. Calculus Review. For us, the concentration vs. time. > 0 then X is increasing. < 0 then X is decreasing. Law of Mass Action.

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Miap

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  1. NGF-P75 Miap Casp6 Casp3 N Modeling Apoptosis

  2. f(NGF) NGF NGF p75

  3. NGF-P75 Miap Casp6 Casp3 N

  4. LAW OF MASS ACTION

  5. Calculus Review For us, the concentration vs. time > 0 then X is increasing < 0 then X is decreasing

  6. Law of Mass Action • Rate of any given chemical reaction is proportional to the product of the concentrations of the reactants. • Example: with reaction rate • Rate of change of concentration of A: • Rate of change of concentration of B: • Rate of change of concentration of C: • [A], [B], concentration of respective chemicals, t is time.

  7. A B C +

  8. Law of Mass Action (Cont.) • Many reactions are reversible: e.g. , forward rate constant, , reverse rate constant. • After applying the law of mass action:

  9. Deer Wolf

  10. f(NGF) Miap Casp6 Casp3

  11. When a is positive, c6 will increase forever!

  12. f(NGF) Miap Casp6 Casp3 N

  13. Now what does it do?

  14. Miap Casp6 Casp3 Simplification

  15. Casp6 Casp3 N So what happens? The Cell May Die

  16. Casp6 Casp3 N So what happens? The Cell May Live

  17. The Casp6 Equation The Cell May Die The Cell May Live

  18. The Miap Equation

  19. Casp6 Casp3 Cell Lives When N Exactly when does the cell die?

  20. Casp6 Cell Lives When Casp3 Cell Will Probably Die N Cell Will Probably Live When does the cell die?

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