Metals in medicine research university of wollongong
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Institute for Biomolecular Science (IBS) 14 Academic Staff Dept. of Chemistry Dept. of Biology 9 Postdocs 30 PhD Students B. Med Chem B. Biotech. Project areas include: Drug design and development Biomolecular structure determination Cellular and molecular biology

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Metals in Medicine Research University of Wollongong

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Metals in medicine research university of wollongong

Institute for Biomolecular Science (IBS)

14 Academic Staff

Dept. of Chemistry

Dept. of Biology

9 Postdocs

30 PhD Students

B. Med Chem

B. Biotech

Project areas include:

Drug design and development

Biomolecular structure determination

Cellular and molecular biology

Food and natural product chemistry

Mechanism of cataract formation

Metals in Medicine Research University of Wollongong


Interactions of gold drugs with proteins

Interactions of Gold Drugs with Proteins


How does chrysotherapy work

How does Chrysotherapy Work?

  • Many possible mechanisms of action:

    • Anti-inflammatory

    • Inhibition of lysosomal enzymes

    • Immunomodulatory activity

    • Effects on metabolism of reactive oxygen

  • All gold drugs rapidly bind to proteins containing thiol side chains, but not DNA.

  • [Au(CN)2]- is a common metabolite of all Au drugs

  • Au(I) oxidised to Au(III) in vivo


Esi ms of human serum albumin hsa

ESI-MS of Human Serum Albumin (HSA)

J. Croft, CHEM340, 2004


Reaction between au pet 3 cl and metallothionein

Reaction between [Au(PEt3)Cl] and Metallothionein

S. Ambehara, B.Sc(Hons), 20002


Covalent binding of ruthenium compounds to dna

Covalent Binding of Ruthenium Compounds to DNA

J. Torrens, B.Sc(Hons), 2000


Non covalent interactions between ruthenium complexes and dna

Non-covalent Interactions Between Ruthenium Complexes and DNA

J. Aldrich-Wright and co-workers


Esi ms of d2

ESI-MS of D2

[D2-6H]6-

[D2-5H]5-

T. Urathamakul, B.Sc(Hons), 2002


Esi ms of ru phen 2 dpqc 2 mol wt 748

ESI-MS of [Ru(phen)2(dpqC)]2+(mol. wt = 748)

T. Urathamakul, B.Sc(Hons), 2002


Reactions between ru phen 3 2 and d2

Reactions between [Ru(phen)3]2+ and D2

T. Urathamakul, B.Sc(Hons), 2002

Ru:D2 = 5:1

Ru:D2 = 10:1

Ru:D2 = 20:1

Ru:D2 = 30:1

Ru:D2 = 50:1


Reactions between ru phen 2 l 2 and d2

Reactions between [Ru(phen)2L]2+ and D2

L = phen

L = pda

L = dpq

L = dpqMe2

L = dpqC

T. Urathamakul

B.Sc(Hons), 2002

L = dppz


Future work

Future Work

  • Binding of mono- and poly-nuclear ruthenium complexes to longer DNA and DNA containing other base sequences

  • Binding of gold, vanadium, bismuth, ruthenium and other metal-containing drugs to proteins including HSA, MT and Transferrin


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