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Load the nodes and modes with query pathway into memory

START. Load the nodes and modes with query pathway into memory. Retrieve protein sequence for each node. i = i +1, looping. last pathway in pathway_db. no. yes.

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Load the nodes and modes with query pathway into memory

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  1. START Load the nodes and modes with query pathway into memory Retrieve protein sequence for each node i = i +1, looping last pathway in pathway_db no yes For each node, find orthogonal node in the comparing pathway. Align the modes and nodes based on the orthogonal nodes Sort the hits by overall score Generate graphic output Generate overall score by summarizing all the matched nodes and matched modes Display the screen END

  2. Display on the screen according to the order of overall score Fit each orthologous protein into the hit pathway, inherit all interaction modes For each matching species, generate graphic output END yes j = j +1, looping for all protein nodes Load the nodes and modes with query pathway into memory Retrieve protein sequence for each node START no For each node, BLASTp vs. protein_db to find orthogonal node in the matching species Store those top-hits in the matching species that is above threshold last protein in query pathway in pathway_db

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