Best New Life Sciences Company in Scotland 2013

1. SVOP Applications, features and benefits Best New Life Sciences Company in Scotland 2013

2. The SVOP: An Overview • The SVOP is a Saccadic Vector Optokinetic Perimeter • The SVOP is a visual field analyser invented at the Royal Hospital for Sick Children in Edinburgh, UK and commercialised by i2eye Diagnostics Ltd. • The SVOP was developed to meet a clinical need to screen young children and those unable to perform a standard visual field. • The SVOP is easy and intuitive to use by both patients and operators. It can screen patients from under one year old to over 70 • The SVOP produces a standard visual field plot familiar to all eye-care professionals.

3. How Does the SVOP Work? • There is an introductory video to the SVOP on i2eye’s website at: www.i2eyediagnostics.com • The SVOP has an eye-tracker to continuously monitor the patient’s gaze direction and distance from the instrument. It uses this information to: • Confirm their fixation, • Accurately place target images within the central 30 degrees of their visual field and, • Record their response by tracking their eye movement as they react to the appearance of the target.

4. The SVOP Printout

5. The SVOP Patient Benefits • Patient comfort • Free head movement • No head or chin rest • No physical contact with the instrument • Some movement allowed • Concentration benefits • Simple intuitive test, no complex instructions • Response recorded objectively without considered feedback from the patient • Test normally complete within three minutes

6. Coverage of Conventional VF’s • Conventional automatic static perimeters can screen approx. 60 % of the population who are aged between 10 and 70 years and are neurologically normal. • Young children, the frail elderly and those with compromised neurological function cannot be screened reliably

7. Coverage of the SVOP • The SVOP can screen over 85% of the population aged between one and >70 years who are neurologically normal • Infants and the frail elderly can be screened reliably • A proportion of neurologically compromised subjects can be tested

8. The SVOP Advantage • The SVOP is a rapid automatic screening test suitable for >90 % of neurologically normal subjects with normal eyes • The SVOP is suitable for all ages from one to over 70 years • A normal result has a 95% confidence level • An abnormal or ambiguous result requires further investigation • Low operator skill (nurse, technician etc) • Low patient stress • 2 minute test • Central 30 degree field

9. The correct patient • Understand current limitations • Neurologically intact with normal eyes 95% success • Brain tumours/discreet lesions approx. 50% success • Paediatric stroke approx. 30% success rates • Cerebral palsy <10% success Research Horizons No engagement No calibration • The patient must engage and calibrate • 5-10% of patients will not look at or maintain engagement with the screen • Too few calibration points for accurate tracking • Eyetracker line of sight blocked – hair, glasses, dry eyes, deep-set eyes • Abnormal eye does not fit model – switch to KidzEyez or other method Calibrates but is unreliable • Principal research opportunities • 30-50% of neurologically compromised patients give inconsistent results that are not as anticipated • Condition specific normative data, analysis and interpretation necessary to improve performance of SVOP- collaboration, Open Innovation Calibrates and tests • Screening and testing • Screens 95% of the neurologically healthy population • Rapidly (2 minutes) identifies those who require further investigation • Frees resources to concentrate in areas of need • Ongoing internal and collaborative research is continually improving reach

10. Research Horizons for the SVOP • SVOP is a new generation of visual function tester. • There are research opportunities to improve its reach into testing severely neurologically compromised individuals • i2eye actively encourages collaborative and third-party research through Open Innovation

11. Key Users Dr Gena Heidary Dr Constance West Dr Luisa Mayer Mr Michael Clarke Prof. Birgit Lorenz

12. Availability • SVOP is commercially available now in: • Europe (CE marked class 2a medical device) • Australia (TGA approved class 2a medical device) • USA (FDA listed class 1 medical device exempt from 510(k) • SVOP costs (POA) including: • Delivery and training • 12 month warranty • 12 month software updates including those that enhance performance or reach. • Email and telephone support • Ongoing maintenance contracts from Euro 1000 per year

13. Clinical References Visual Field assessment in infants using Saccadic Vector OptokineticPerimetry BIPOSA 2013, invited verbal presentation, Brian Fleck Saccadic Vector OptokineticPerimetry (SVOP): A novel technique for automated static perimetry in children using eye tracking. Murray I, Perperidis A, Brash H, Cameron L, McTrusty A, Fleck B, Minns R. ConfProc IEEE Eng Med Biol Soc. 2013;2013:3186-9. doi: 10.1109/EMBC.2013.6610218. PMID: 24110405 [PubMed - in process] Visual field measurement in infants and young children with neurological disorders using saccadic vector optokineticperimetry (SVOP). Brian W. Fleck, Ian Murray, Harry Brash, Robert Minns Journal of AAPOS February 2012 (Vol. 16, Issue 1, Page e5) Feasibility of saccadic vector optokineticperimetry: a method of automated static perimetry for children using eye tracking. Murray IC, Fleck BW, Brash HM, Macrae ME, Tan LL, Minns RA. Ophthalmology. 2009 Oct;116(10):2017-26. doi: 10.1016/j.ophtha.2009.03.015. Epub 2009 Jun 27. PMID: 19560207 [PubMed - indexed for MEDLINE] 093: Automated visual field assessment in young children using eye tracking—preliminary data from 9 children Ian C. Murray, Mary E. MacRae, Brian W. Fleck, Harry M. Brash, Lai L. Tan, Robert A. Minns Journal of AAPOS February 2009(Vol. 13, Issue 1,Page e24)

14. Contact i2eye Diagnostics ltd 9 Edinburgh BioQuarter Little France Edinburgh EH16 4UX UK T: +44 (0) 131 658 5154 E: contact@i2eyediagnostics.com W: www.i2eyediagnostics.com In the USA Steve Elfrink: Steve.Elfrink@i2eyediagnostics.com Phone: 608-632-0914