Anti-Coagulants
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Anti-Coagulants. Physical Process of Clotting Chemical Process of Clotting Fibrin formation, extrinsic and intrinsic pathways Anti-coagulants Definition Heparin, Low molecular weight heparins, pentasaccharide Structure, properties, biochemical mechanism Coumarins and 1,3-indanediones

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Anti-Coagulants

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Medc 604 anti coagulants

Anti-Coagulants

  • Physical Process of Clotting

  • Chemical Process of Clotting

    Fibrin formation, extrinsic and intrinsic pathways

  • Anti-coagulants

    Definition

  • Heparin, Low molecular weight heparins, pentasaccharide

    Structure, properties, biochemical mechanism

  • Coumarins and 1,3-indanediones

    Structure, properties, biochemical mechanism

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

A) Physical Process B) Chemical Process

Wound

Wound

aspirin

antithrombins

platelet activation

factor Xa

fibrinogen

release thrombin release of

of ADP generation thromboxane A2

thrombin prothrombin

fibrin

(monomers)

vitamin K-dependent

g-carboxylation of

Glu residues

Further activation of platelets

ADP

receptor

antagonists

GP IIb-IIIa

receptor

antagonists

fibrin

(polymer)

Platelet aggregation

coumarins

CLOT

The Clotting Process

Taken from Desai UR (2004) Med. Res. Rev. 24, 151-181.

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Physical Process of Clotting

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Chemical Process of Clotting

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Heparin and Low molecular weight heparins

Structure and sequence

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Pentasaccharide

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

AT + H

AT:H

AT-E + H

E

Biochemical Mechanism of Heparin Action

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Direct Thrombin Inhibitors

HIRUDIN – Isolated from leech, hirudino medicinalis. A polypeptide consisting of 65 amino acid residues that binds thrombin in the active site as well as another site called exosite I

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Coumarins and 1,3-indanediones

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Clinically useful coumarins and 1,3-indanediones

MEDC 604 Anti-coagulants


Medc 604 anti coagulants

Biochemical Mechanism of Action

MEDC 604 Anti-coagulants


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