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Anti-Coagulants

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MEDC 604 Anti-coagulants - PowerPoint PPT Presentation


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Anti-Coagulants. Physical Process of Clotting Chemical Process of Clotting Fibrin formation, extrinsic and intrinsic pathways Anti-coagulants Definition Heparin, Low molecular weight heparins, pentasaccharide Structure, properties, biochemical mechanism Coumarins and 1,3-indanediones

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slide1

Anti-Coagulants

  • Physical Process of Clotting
  • Chemical Process of Clotting

Fibrin formation, extrinsic and intrinsic pathways

  • Anti-coagulants

Definition

  • Heparin, Low molecular weight heparins, pentasaccharide

Structure, properties, biochemical mechanism

  • Coumarins and 1,3-indanediones

Structure, properties, biochemical mechanism

MEDC 604 Anti-coagulants

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A) Physical Process B) Chemical Process

Wound

Wound

aspirin

antithrombins

platelet activation

factor Xa

fibrinogen

release thrombin release of

of ADP generation thromboxane A2

thrombin prothrombin

fibrin

(monomers)

vitamin K-dependent

g-carboxylation of

Glu residues

Further activation of platelets

ADP

receptor

antagonists

GP IIb-IIIa

receptor

antagonists

fibrin

(polymer)

Platelet aggregation

coumarins

CLOT

The Clotting Process

Taken from Desai UR (2004) Med. Res. Rev. 24, 151-181.

MEDC 604 Anti-coagulants

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Physical Process of Clotting

MEDC 604 Anti-coagulants

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Chemical Process of Clotting

MEDC 604 Anti-coagulants

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Heparin and Low molecular weight heparins

Structure and sequence

MEDC 604 Anti-coagulants

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Pentasaccharide

MEDC 604 Anti-coagulants

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AT + H

AT:H

AT-E + H

E

Biochemical Mechanism of Heparin Action

MEDC 604 Anti-coagulants

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Direct Thrombin Inhibitors

HIRUDIN – Isolated from leech, hirudino medicinalis. A polypeptide consisting of 65 amino acid residues that binds thrombin in the active site as well as another site called exosite I

MEDC 604 Anti-coagulants

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Coumarins and 1,3-indanediones

MEDC 604 Anti-coagulants

slide11

Biochemical Mechanism of Action

MEDC 604 Anti-coagulants

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