VIROLOGY. Allgemeine Virologie I. Introduction in Virology. History January 1796 vaccination against smallpox virus. Virus. Definition of virus Basic properties of viruses Morphology – Structures of virues Replication Classification. Bacteriophage. Basic Virology.
Allgemeine Virologie I
Introduction in Virology
January 1796 vaccination against smallpox virus
Effect of viral replication CPE – Pathogenesis
Edward Jenner (1749-1823):
European governments have officially encouraged or compelled the practise; and smallpox has ceased to be the almost universal scourge it was before Jenner's discovery.
Modern History Sourcebook
Some are asymptomatic!
“A PIECE OFBAD NEWSWRAPPED UP IN A PROTEIN”
1. smallest infectious agents
2. one kind of nucleic acid (RNA or DNA)
3. intracellular parasites
4. assembly of the individual components
5. not usually respond to antibiotics
Virion: the complete fully assembled virus, serves to transfer the viral nucleic acid
Range: from 20nm to 300nm in diameter
Shapes: spheres, rods, bullets, bricks, tadpoles
A complete infectious particle of virus
( 65 ×95nm )
( 40nm )
( 100nm )
Shapes of viruses
Shapes of Viruses :Rod-shaped
Shapes of Viruses :Brick-shaped
Shapes of Viruses:Bullet-shaped
Shapes of Viruses :Filament
Function: It provide the information of reproduction, heredity and mutation.
The functions of capsid:
 Viral protein
 Viral nucleic acid
 Viral lipid
 Viral glycoprotein
1.The structural proteins of viruses:
(1) Capsid protein
(2) Basic core protein
These proteins are necessary to package the nucleic acid within the capsid !
2. The non-structural proteins
The non-structural proteins are other proteins such as enzymes that are needed for the production of viral components but are not part of the virion.
Viral protein function:
1. Protect the nucleic acid
2. Take part in infection
Six different classes can be distinguished, based on mechanisms of transcription.
1. +-dsDNA 2.+ssDNA
3. +- dsRNA 4.+ssRNA
5.–ssRNA 6.Retroviruses +ssRNA
mediate the attachment of the virus to specific receptors on the host cell surface