Algorithmic Approach to Diagnosis of Hydatidiform Moles

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Algorithmic Approach to Diagnosis of Hydatidiform Moles

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Algorithmic Approach to Diagnosis of Hydatidiform Moles

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Possible Hydatidiform Mole

p57 immunohistochemistry

Negative p57

(villous stroma, cytotrophoblast)

Positive p57

(villous stroma, cytotrophoblast)

Morphology appropriate

Morphology equivocal

Molecular genotyping

Androgenetic diploidy

Diandric triploidy

Biparental diploidy

CHM or eCHM

PHM

Non-molar

Supplemental figure legend:

Algorithmic approach to diagnosis of hydatidiform moles. Potential molar cases are first triaged with p57 immunohistochemistry. If p57 is negative and morphology is appropriate, a diagnosis of complete hydatidiform mole (CHM) or early complete hydatidiform mole (eCHM) can be rendered. If p57 is positive, molecular genotyping is performed (regardless of morphology). The subtypes of molar specimens, including CHMs and partial hydatidiform moles (PHM) are distinguished from non-molar specimens by the specific genotyping results indicated.